Sexual Well-Being After Nipple-Sparing Mastectomy: Does Preservation of the Nipple Matter?

Introduction The primary aim of this study was to evaluate patient-reported outcome measures in patients undergoing mastectomy with and without breast reconstruction (immediate or delayed) with and without nipple preservation. Methods All female patients undergoing mastectomy between 2011 and 2015 a...

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Published in:Annals of surgical oncology 2022-07, Vol.29 (7), p.4167-4179
Main Authors: Racz, Jennifer M., Harless, Christin A., Hoskin, Tanya L., Day, Courtney N., Nguyen, Minh-Doan T., Harris, Ann M., Boughey, Judy C., Hieken, Tina J., Degnim, Amy C.
Format: Article
Language:English
Subjects:
Breast
Breast Oncology
Breasts
Mastectomy
Medicine
Medicine & Public Health
Oncology
Patients
Preservation
Reconstructive surgery
Surgery
Surgical Oncology
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Summary:Introduction The primary aim of this study was to evaluate patient-reported outcome measures in patients undergoing mastectomy with and without breast reconstruction (immediate or delayed) with and without nipple preservation. Methods All female patients undergoing mastectomy between 2011 and 2015 at Mayo Clinic Rochester were identified and were mailed the BREAST-Q survey. Breast satisfaction, psychosocial well-being, and sexual well-being were evaluated and compared by surgery type using Wilcoxon rank-sum tests for univariate analysis and linear regression for multivariable analysis adjusting for potential confounders. Results Of 1547 patients, 771 completed the BREAST-Q survey (response rate 50%). Of these 771 respondents, 237 (31%) did not have reconstruction, 198 (26%) had nipple-sparing mastectomy with reconstruction (NSM), and 336 (44%) had skin-sparing mastectomy with reconstruction (SSM) ± nipple–areolar complex (NAC) reconstruction (via surgery ± tattoo). Patients with breast reconstruction had consistently higher BREAST-Q scores versus those without. Comparing NSM with all SSMs, there was no difference in satisfaction with breasts (mean 71.8 vs. 70.2, p  = 0.21) or psychosocial well-being (mean 81.9 vs. 81.3, p  = 0.47); however, sexual well-being was significantly higher in the NSM group on univariate (mean 64.5 vs. 58.0, p  = 0.002) and multivariable ( β  = −4.69, p  = 0.03) analysis. Sexual well-being scores were similar for NSM and the SSM subgroups with any type of NAC reconstruction. Conclusions This study demonstrates that NSM positively impacts patient sexual well-being after breast reconstruction compared with SSM, particularly SSM without nipple reconstruction or tattoo. SSM with any type of NAC reconstruction achieved similar satisfaction and sexual well-being to those undergoing NSM.
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-022-11578-1