Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity

Obesity develops from an imbalance of energy homeostasis and is associated with the development of metabolic disorders, including insulin resistance and type 2 diabetes. Identification of the underlying molecular mechanisms and effective therapeutic approaches is highly needed. Lysine-specific demet...

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Bibliographic Details
Published in:The Journal of nutrition 2022-07, Vol.152 (7), p.1611-1620
Main Authors: Wang, Dan, Kuang, Yanling, Zhang, Guolong, Xiao, Kan, Liu, Yulan
Format: Article
Language:English
Subjects:
Adenine
adipose tissue
Biological activity
Body fat
Body temperature
Body weight
Cell fate
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Embryogenesis
Embryonic growth stage
Energy balance
energy homeostasis
Energy Metabolism
Flavin
Glucose
Glucose metabolism
Histone Demethylases - metabolism
Homeostasis
Humans
Insulin
Insulin resistance
Lipid metabolism
Lipids
LSD1
Lysine
Lysine - metabolism
Medical research
metabolic diseases
Metabolic disorders
Metabolism
Mitochondria
Molecular modelling
Nutrients
Nutrition
Obesity
Phenotypes
Physiological effects
Physiology
Stem cells
Thermogenesis
Tumorigenesis
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Summary:Obesity develops from an imbalance of energy homeostasis and is associated with the development of metabolic disorders, including insulin resistance and type 2 diabetes. Identification of the underlying molecular mechanisms and effective therapeutic approaches is highly needed. Lysine-specific demethylase 1 (LSD1), an flavin adenine dinucletide-dependent amine oxidase, is implicated in a wide variety of biological processes, including tumorigenesis, stem cell fate decisions, and embryonic development. Recent studies have suggested a vital role of LSD1 in regulating adaptive thermogenesis, mitochondrial biogenesis, glucose, and lipid metabolism. More recently, LSD1 activity was found to be regulated by nutrients, energy status, and hormonal signals, suggesting that it may act as a novel sensor for nutritional regulation of metabolic health. Here, we first discuss the effects of LSD1 on physiological phenotypes, including body weight, fat mass, body temperature, and glucose homeostasis. We also summarize recent understanding of the physiological roles and underlying mechanisms of LSD1 in controlling metabolic functions of adipose and other tissues. Hopefully, a better understanding of the roles of LSD1 in metabolic regulation may provide new perspectives for the nutritional prevention and treatment of obesity.
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/nxac080