Relation Between Frailty and 1-Year Outcomes After Implantation of a Left Ventricular Assist Device

Frailty has been associated with morbidity and mortality in patients with heart failure and those who underwent cardiac surgery. We aimed to study the effect of frailty on cardiovascular outcomes and the reversibility of frailty after the left ventricular assist device (LVAD) implantation. A total o...

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Bibliographic Details
Published in:The American journal of cardiology 2022-06, Vol.173, p.88-93
Main Authors: Uzun, Hakan Gökalp, Simsek, Evrim, Engin, Cagatay, Yagdi, Tahir, Karapolat, Hale, Ozbaran, Mustafa, Nalbantgil, Sanem
Format: Article
Language:English
Subjects:
Age
Body mass index
Cognition
Cognitive ability
Confidence intervals
Congestive heart failure
Electrocardiography
Fibrillation
Frailty
Gender
Heart surgery
Hemorrhage
Implantation
Length of stay
Mental depression
Morbidity
Mortality
Patients
Phenotypes
Questionnaires
Renal function
Statistical analysis
Statistics
Surgery
Tachycardia
Ventricle
Ventricular fibrillation
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Summary:Frailty has been associated with morbidity and mortality in patients with heart failure and those who underwent cardiac surgery. We aimed to study the effect of frailty on cardiovascular outcomes and the reversibility of frailty after the left ventricular assist device (LVAD) implantation. A total of 51 consecutive patients (44 men; aged 54 ± 10 years) scheduled to undergo LVAD implantation were assessed for frailty (Fried's phenotype, frail ≥3/5), cognitive function (using Mini-Cog), and depression (utilizing Patient Health Questionnaire-9) before the surgery and 3 months afterward. Patients were observed for mortality and adverse events [all-cause readmission, bleeding, renal dysfunction, and ventricular fibrillation (VF)/sustained ventricular tachycardia (VT)] for 12 months. More than half of the patients (54%) were designated as frail. Although there was no statistical difference in mortality among frail and nonfrail patients, frail ones were more likely to have a prolonged length of stay [adjusted odds ratio (AOR) 14.9, 95% confidence interval 1.6 to 132.5, p = 0.01]. At the 3-month reassessment after operation, frailty and cognition rates were better (frailty score [lower is better]: 3 vs 1.5, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2022.02.041