Hepatic drug metabolism in older people with body composition changes

Aim Dosage adjustment is essential in older individuals because they are prone to experience a decline in liver function and changes in body composition. However, quantitative tests or equations for evaluating the activity of hepatic drug metabolism have not yet been clearly established. We examined...

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Bibliographic Details
Published in:Geriatrics & gerontology international 2022-05, Vol.22 (5), p.449-454
Main Authors: Kaburaki, Soyoko, Yoshimura, Eri, Miyamoto, Yasushi, Imai, Shungo, Kashiwagi, Hitoshi, Ueno, Hidefumi, Sugawara, Mitsuru, Takekuma, Yoh
Format: Article
Language:English
Subjects:
Aged
Body Composition
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP3A
Female
Hand Strength
handgrip strength
hepatic drug metabolism
Humans
Lansoprazole
Liver
Male
Metabolism
Nifedipine
older patients
Older people
Sarcopenia
skeletal muscle mass
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Summary:Aim Dosage adjustment is essential in older individuals because they are prone to experience a decline in liver function and changes in body composition. However, quantitative tests or equations for evaluating the activity of hepatic drug metabolism have not yet been clearly established. We examined hepatic drug metabolism activities in older individuals, focusing on changes in body composition parameters. Methods Lansoprazole and nifedipine, substrates of the metabolic enzymes cytochrome P450 (CYP) 2C19 and 3A4, respectively, were selected to study hepatic drug metabolism. Residual samples from blood test for older patients were evaluated to determine drug metabolism. The body composition of relevant patients was determined by analyzing characteristic parameters of skeletal muscle mass index (SMI), handgrip strength (HGS) and hepatic steatosis index (HSI). The differences in hepatic drug metabolism were studied statistically among categories in terms of the cut‐off value of these parameters. Results Older male patients receiving lansoprazole and nifedipine in the low SMI (
ISSN:1444-1586
1447-0594
DOI:10.1111/ggi.14380