Physical activity reduces the role of blood cadmium on depression: A cross-sectional analysis with NHANES data

Cadmium (Cd) exposure is recognized as an important risk factor for psychological health, but suitable physical activity may relieve depression. However, it remains unknown whether physical activity (PA) can reduce the effect of cadmium exposure on depression. Therefore, a cross-sectional data from...

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Published in:Environmental pollution (1987) 2022-07, Vol.304, p.119211-119211, Article 119211
Main Authors: Tian, Xiaoyu, Xue, Baode, Wang, Bo, Lei, Ruoyi, Shan, Xiaobing, Niu, Jingping, Luo, Bin
Format: Article
Language:English
Subjects:
Adult
Cadmium
Cross-Sectional Studies
Depression
Depression - epidemiology
Exercise
Humans
National health and nutrition examination survey
Nutrition Surveys
Physical activity
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Summary:Cadmium (Cd) exposure is recognized as an important risk factor for psychological health, but suitable physical activity may relieve depression. However, it remains unknown whether physical activity (PA) can reduce the effect of cadmium exposure on depression. Therefore, a cross-sectional data from National Health and Nutrition Examination Survey (NHANES) 2015–2018 was used. The Nine-item Patient Health Questionnaire (PHQ-9) was used to assess depression among the participants. PA was calculated according to the metabolic equivalent (MET), weekly frequency, and duration of each activity. Logistic regression and restricted cubic spline models were used to examine the associations of Cd and depression. A total of 5560 adults aged 20 years and above were finally included in this study. The results indicated a positive correlation between blood Cd and depression. The multivariate-adjusted ORs (95% CI) of the highest quartile were 2.290 (1.754–2.990) for depression, which was still significant after controlling other heavy metals (P 
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2022.119211