Silver-loaded carboxymethyl cellulose nonwoven sheet with controlled counterions for infected wound healing

Carboxymethyl cellulose (CMC) is a promising material for moist wound healing, and silver loading onto CMC has been examined for anti-bacterial activity. In this study, we developed silver-loaded CMC nonwoven sheets with different counterions, namely sodium CMC (CMC-Na/Ag) and partially protonated C...

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Bibliographic Details
Published in:Carbohydrate polymers 2022-06, Vol.286, p.119289-119289, Article 119289
Main Authors: Ohta, Seiichi, Mitsuhashi, Kento, Chandel, Arvind K. Singh, Qi, Pan, Nakamura, Noriko, Nakamichi, Akiko, Yoshida, Hiromi, Yamaguchi, Gento, Hara, Yuichi, Sasaki, Ryo, Fuke, Masaya, Takai, Madoka, Ito, Taichi
Format: Article
Language:English
Subjects:
Animals
Anti-bacterial
Bandages
Carboxymethyl cellulose
Carboxymethylcellulose Sodium - pharmacology
Counterions
Mice
Silver - pharmacology
Silver - therapeutic use
Silver release
Wound dressings
Wound Healing
Wound Infection - drug therapy
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Summary:Carboxymethyl cellulose (CMC) is a promising material for moist wound healing, and silver loading onto CMC has been examined for anti-bacterial activity. In this study, we developed silver-loaded CMC nonwoven sheets with different counterions, namely sodium CMC (CMC-Na/Ag) and partially protonated CMC (CMC-H/Ag), to examine their anti-bacterial and wound-healing properties. Owing to the presence of counter protons, CMC-H/Ag showed slower water adsorption, dissolution, and Ag release than CMC-Na/Ag. In addition, CMC-H/Ag and CMC-Na/Ag exhibited differences in anti-bacterial activities in shake-flask and inhibition zone tests in vitro. An in vivo experiment using a pressure ulcer mouse model with Pseudomonas aeruginosa infection showed that CMC-Na/Ag significantly accelerated wound healing compared to CMC-H/Ag and a commercially available Ag-loaded CMC nonwoven sheet, Aquacel Ag. These results suggest the importance of controlling CMC counterions and the therapeutic potential of the developed product as a wound dressing. [Display omitted]
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2022.119289