Relationship between the Thyroid Function and Cognitive Impairment in the Elderly in Japan

Objective The reference ranges of serum thyroid hormone levels are determined by the values of normal subjects aged 15 or 20 to 60 years old in Japan and may differ from the values in elderly patients. In addition, the relationship between the thyroid function and cognitive function remains controve...

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Bibliographic Details
Published in:Internal Medicine 2022/10/15, Vol.61(20), pp.3029-3036
Main Authors: Furuto-Kato, Sumiko, Araki, Atsushi, Chiba, Yuko, Nakamura, Michizou, Shintani, Mitsuyo, Kuwahara, Takashi, Yamakage, Hajime, Satoh-Asahara, Noriko, Tagami, Tetsuya
Format: Article
Language:English
Subjects:
Age
Age groups
Cognitive ability
cognitive impairment
elderly subjects
Gender
Hormones
Internal medicine
Steroid hormones
Thyroid gland
thyroid hormone
Thyroid hormones
Thyroid-stimulating hormone
Thyroxine
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Summary:Objective The reference ranges of serum thyroid hormone levels are determined by the values of normal subjects aged 15 or 20 to 60 years old in Japan and may differ from the values in elderly patients. In addition, the relationship between the thyroid function and cognitive function remains controversial. We assessed the thyroid function of elderly subjects ≥60 years old and its impact on the cognitive function in Japanese adults. Methods We compared the thyroid function by age group and gender and investigated the effects of cognitive impairment on the thyroid function. This study was a cross-sectional, multi-institutional joint study. Patients The serum concentrations of thyroid hormones in 1,136 patients were measured; however, those taking thyroid hormones, anti-thyroid drugs, and steroid hormones were excluded. Among them, 1,016 cases in which the cognitive function was evaluated were divided into five groups according to their free thyroxine (FT4) levels. Results Excluding overt thyroid dysfunction (5.8%), the average age of the 1,070 remaining patients was 77.5 years old. The rate of cognitive impairment was lowest at FT4 levels of 1.1-1.2 ng/dL and highest at FT4 levels
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9034-21