Polymer-based nanostructures loaded with piperine as a platform to improve the larvicidal activity against Aedes aegypti

•Nanostructures were spherical in shape with narrow size distribution and excellent encapsulation.•Nanostructures promoted slow release of piperine, increasing its activity over time.•Piperine in nanostructured systems can be an effective tool to control of Ae. aegypti. Piperine is an alkaloid extra...

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Published in:Acta tropica 2022-06, Vol.230, p.106395-106395, Article 106395
Main Authors: de Oliveira, Joice Guilherme, Pilz-Júnior, Harry Luiz, de Lemos, Alessandra Bittencourt, da Silva da Costa, Felipe Allan, Fernandes, Millena, Gonçalves, Douglas Zelinger, Variza, Paula Fassicolo, de Moraes, Fernanda Mendes, Morisso, Fernando Dal Pont, Magnago, Rachel Faverzani, Zepon, Karine Modolon, Kanis, Luiz Alberto, da Silva, Onilda Santos, Prophiro, Josiane Somariva
Format: Article
Language:English
Subjects:
Larvicidal activity
Piper
piperine
polymer-based nanostructures
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Summary:•Nanostructures were spherical in shape with narrow size distribution and excellent encapsulation.•Nanostructures promoted slow release of piperine, increasing its activity over time.•Piperine in nanostructured systems can be an effective tool to control of Ae. aegypti. Piperine is an alkaloid extracted from the seed of Piper spp., which has demonstrated a larvicidal effect against Ae. aegypti. The incorporation of piperine into nanostructured systems can increase the effectiveness of this natural product in the control of Ae. aegypti larvae. In this study, we evaluated the effectiveness of piperine loaded or not into two nanostructured systems (named NS-A and NS-B) prepared by the nanoprecipitation method. The Ae. aegypti larvae were exposed to different concentrations of piperine loaded or not (2 to 16 ppm) and the mortality was investigated after 24, 48, and 72 hours. The nanostructures prepared were spherical in shape with narrow size distribution and great encapsulation efficiency. The lethal concentration 50 (LC50) for non-loaded piperine were 13.015 ppm (24 hours), 8.098 ppm (48 hours), and 7.248 ppm (72 hours). The LC50 values found for NS-A were 35.378 ppm (24 hours), 12.091 ppm (48 hours), and 8.011 ppm (72 hours), whereas the values found for NS-B were 21.267 ppm (24 hours), 12.091 ppm (48 hours), and 8.011 ppm (72 hours). Collectively, these findings suggested that non-loaded piperine caused higher larval mortality in the first hours of exposure while the nanostructured systems promoted the slow release of piperine and thereby increased the larvicidal activity over time. Therefore, loading piperine into nanostructured systems might be an effective tool to improve the larval control of vector Ae. aegypti.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2022.106395