Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of Panax notoginseng

has been used both as a traditional medicine and as a functional food for hundreds of years in Asia. However, the active constituents from and their pharmacologic properties still need to be further explored. In this study, one new dammarane-type triterpenoid saponin (1), along with fourteen known a...

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Bibliographic Details
Published in:Food & function 2022-03, Vol.13 (6), p.3590-3602
Main Authors: Zheng, Yuan-Ru, Fan, Chun-Lin, Chen, Ye, Quan, Jing-Yu, Shi, Ling-Zhu, Tian, Chun-Yang, Shang, Xiao, Xu, Ni-Shan, Ye, Wen-Cai, Yu, Lin-Zhong, Liu, Jun-Shan
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Anti-Inflammatory Agents - metabolism
Anti-Inflammatory Agents - pharmacology
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Dammaranes
Danio rerio
Dengue fever
Functional foods & nutraceuticals
Inflammation
Inflammatory response
MyD88 protein
NF-κB protein
Panax
Panax notoginseng
Plant Roots - metabolism
Replication
Roots
Saponins
Saponins - metabolism
Saponins - pharmacology
Stat3 protein
Triterpenes
Vector-borne diseases
Viruses
Zebrafish
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Summary:has been used both as a traditional medicine and as a functional food for hundreds of years in Asia. However, the active constituents from and their pharmacologic properties still need to be further explored. In this study, one new dammarane-type triterpenoid saponin (1), along with fourteen known analogs (2-15) were isolated and identified from the roots of . The anti-inflammatory, anti-angiogenetic and anti-dengue virus effects of these isolated compounds were further evaluated. Compounds 1, 3, 5-7 and 10-12 exerted anti-inflammatory effects in two different zebrafish inflammatory models. Among them, 11, with the most significant activities, alleviated the inflammatory response by blocking the MyD88/NF-κB and STAT3 pathways. Moreover, compound 15 showed anti-angiogenetic activities in Tg( ) and Tg( ) zebrafish, while 3 and 5 only inhibited angiogenesis in Tg( ) zebrafish. Additionally, compounds 1, 3, 6, 8, 9 and 12 suppressed the replication of dengue virus either at the viral adsorption and entry stages or at the intracellular replication step. In conclusion, these findings enrich knowledge of the diversity of saponins in and suggest that the dammarane-type triterpenoid saponins from may be developed as potential functional foods to treat inflammation, angiogenesis or dengue-related diseases.
ISSN:2042-6496
2042-650X
DOI:10.1039/d1fo04089h