Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial pyruvate dehydrogenase complex

Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to proliferative stimuli. Zervopoulos et al. (2022) pro...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cell 2022-03, Vol.82 (5), p.886-888
Main Authors: Boyle, Emily, Wilfling, Florian
Format: Article
Language:English
Subjects:
Cell Nucleus - metabolism
Mitochondria - genetics
Mitochondria - metabolism
Pyruvate Dehydrogenase Complex - genetics
Pyruvate Dehydrogenase Complex - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to proliferative stimuli. Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to proliferative stimuli.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2022.02.014