Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats

It remains unclear whether exposure to sevoflurane produces different effects on long-term cognitive function in developing and mature brains. In the present study, Sprague–Dawley neonatal rats at postnatal day (PND) 7 and adult rats (PND 56) were used in all experiments. We performed fear condition...

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Published in:Molecular neurobiology 2022-05, Vol.59 (5), p.2799-2807
Main Authors: Li, Changsheng, Liu, Sufang, Mei, Yixin, Wang, Qingyong, Lu, Xihua, Li, Hongle, Tao, Feng
Format: Article
Language:English
Subjects:
Anesthetics, Inhalation - toxicity
Animals
Animals, Newborn
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cognitive ability
Disks Large Homolog 4 Protein - metabolism
Fear
Fear conditioning
Hippocampus
Hippocampus - metabolism
Memory
Methyl Ethers - toxicity
Neonates
Neurobiology
Neurology
Neurosciences
Postsynaptic density proteins
Rats
Rats, Sprague-Dawley
Rodents
Sevoflurane
Sevoflurane - pharmacology
Synaptic density
Ultrastructure
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Summary:It remains unclear whether exposure to sevoflurane produces different effects on long-term cognitive function in developing and mature brains. In the present study, Sprague–Dawley neonatal rats at postnatal day (PND) 7 and adult rats (PND 56) were used in all experiments. We performed fear conditioning testing to examine long-term fear memory following 4-h sevoflurane exposure. We assessed hippocampal synapse ultrastructure with a transmission electron microscope. Moreover, we investigated the effect of sevoflurane exposure on the expression of postsynaptic protein 95 (PSD-95) and its binding protein kalirin-7 in the hippocampus. We observed that early exposure to sevoflurane in neonatal rats impairs hippocampus-dependent fear memory, reduces hippocampal synapse density, and dramatically decreases the expressions of PSD-95 and kalirin-7 in the hippocampus of the developing brain. However, sevoflurane exposure in adult rats has no effects on hippocampus-dependent fear memory and hippocampal synapse density, and the expressions of PSD-95 and kalirin-7 in the adult hippocampus are not significantly altered following sevoflurane treatment. Our results indicate that sevoflurane exposure produces differential effects on long-term fear memory in neonatal and adult rats and that PSD-95 signaling may be involved in the molecular mechanism for early sevoflurane exposure-caused long-term fear memory impairment.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-021-02629-x