Outcomes of lung metastasis from pancreatic cancer: A nationwide multicenter analysis

Background Although distant metastasis from pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, some single center studies reported that lung metastasis has a favorable prognosis. The aim of this study is to evaluate the prognostic value of site‐specific metastasis after pancreatectomy f...

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Bibliographic Details
Published in:Journal of hepato-biliary-pancreatic sciences 2022-05, Vol.29 (5), p.552-561
Main Authors: Homma, Yuki, Endo, Itaru, Matsuyama, Ryusei, Sho, Masayuki, Mizuno, Shugo, Seyama, Yasuji, Hirano, Satoshi, Aono, Takashi, Kitami, Chie, Morita, Yoshifumi, Takeda, Yutaka, Yoshida, Kazuhiro, Tani, Masaji, Kaiho, Takashi, Yamamoto, Yuzo, Aoki, Hideki, Ogawa, Masao, Niguma, Takefumi, Mataki, Yuko, Kawasaki, Hiroshi, Baba, Hideo, Yokomizo, Hiroshi, Rikiyama, Toshiki, Yamaue, Hiroki, Yamamoto, Masakazu
Format: Article
Language:English
Subjects:
Carcinoma, Pancreatic Ductal - drug therapy
Carcinoma, Pancreatic Ductal - surgery
Chemotherapy
Humans
Inhibitor drugs
Liver Neoplasms - surgery
Lung cancer
lung metastasis
Lung Neoplasms - secondary
Lung Neoplasms - surgery
Medical prognosis
Metastasis
Neoplasm Recurrence, Local - surgery
Pancreatectomy
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - pathology
Prognosis
Retrospective Studies
Survival Rate
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Summary:Background Although distant metastasis from pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, some single center studies reported that lung metastasis has a favorable prognosis. The aim of this study is to evaluate the prognostic value of site‐specific metastasis after pancreatectomy for PDAC, with a focus on lung metastasis. Methods Data from 117 cases of lung metastasis after pancreatectomy were collected retrospectively from 23 institutions in Japan. To compare the sites of metastasis we also collected the data of 134 patients with liver only metastasis, 67 patients with peritoneal only metastasis and 121 patients with locoregional recurrence alone. Results In patients with lung only metastasis, the median time from recurrence to death (RTD) was 23.1 months, which was better in comparison to other sites of recurrence. In lung metastasis group, the patients who underwent pulmonary resection had better long‐term outcomes in comparison to those who did not. (RTD: 29.2 vs 15.2, P 
ISSN:1868-6974
1868-6982
DOI:10.1002/jhbp.1127