Peptides, Exopolysaccharides, and Short-Chain Fatty Acids from Fermented Milk and Perspectives on Inflammatory Bowel Diseases

Crohn’s disease and ulcerative colitis are characterized by chronic inflammatory processes and an imbalanced immune response along the gastrointestinal (GI) tract. Pharmacological treatments have been widely used, although their long-term application has adverse side effects. On the other hand, milk...

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Bibliographic Details
Published in:Digestive diseases and sciences 2022-10, Vol.67 (10), p.4654-4665
Main Authors: Sigala-Robles, Rodrigo, Santiago-López, Lourdes, Hernández-Mendoza, Adrián, Vallejo-Cordoba, Belinda, Mata-Haro, Verónica, Wall-Medrano, Abraham, González-Córdova, Aarón F.
Format: Article
Language:English
Subjects:
Amino acids
Animals
Biochemistry
Colon
Crohns disease
Dairy products
Fatty acids
Fatty Acids, Volatile - metabolism
Feces
Fermentation
Gastroenterology
Hepatology
Humans
Immune response
Immune system
Inflammation
Inflammatory bowel disease
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - metabolism
Large intestine
Medicine
Medicine & Public Health
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Milk
Milk - metabolism
Milk - microbiology
Oncology
Peptides
Review
Transplant Surgery
Ulcerative colitis
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Summary:Crohn’s disease and ulcerative colitis are characterized by chronic inflammatory processes and an imbalanced immune response along the gastrointestinal (GI) tract. Pharmacological treatments have been widely used, although their long-term application has adverse side effects. On the other hand, milks fermented with specific lactic acid bacteria (LAB) have been shown to be useful as alternative or complementary aids. Many metabolites such as peptides, exopolysaccharides, and short-chain fatty acids are produced during milk fermentation. These components have been shown to change the pH of the gastrointestinal lumen, aid intestine mucosal recovery, modulate the microbiota, and reduce the inflammatory response (innate and adaptive immune system), both in vitro and in vivo. Therefore, the objective of the present review is to describe how these bioactive compounds from fermented milk by specific LAB can decrease the deleterious symptoms of inflammatory bowel disease. Graphical Abstract
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-022-07382-2