Anti-tumor alkaloids from Peganum harmala

Six alkaloids peharmalines F–K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibit...

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Published in:Phytochemistry (Oxford) 2022-05, Vol.197, p.113107-113107, Article 113107
Main Authors: Zhang, Qin, Zan, Yan-Hui, Yang, Han-Gao, Yang, Meng-Yue, Liu, Fang-Shen, Li, Sheng-Ge, Peng, Xiao-Hui, Lin, Bin, Li, Zhan-Lin, Li, Da-Hong, Hua, Hui-Ming
Format: Article
Language:English
Subjects:
A549 Cells
Alkaloids
Alkaloids - chemistry
Anti-tumor
Antineoplastic Agents, Phytogenic - chemistry
Hep G2 Cells
Humans
Peganum - chemistry
Peganum harmala L
Plant Extracts - chemistry
The aerial part
Zygophyllaceae
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Summary:Six alkaloids peharmalines F–K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC50 value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC50 values of 16.45 μM and 17.27 μM, respectively. [Display omitted] •Six unreported alkaloids were isolated from the aerial parts of Peganum harmala.•Peharmaline F possesses a rare quinoline-vasicine hybrid skeleton.•3-(4-Hydroxyphenyl)quinoline showed potent inhibition against hepatoma HepG-2 cells.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2022.113107