Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using “assembloids” from patients, characterizing a bimodal me...

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Bibliographic Details
Published in:Cell stem cell 2022-02, Vol.29 (2), p.181-183
Main Authors: Fernando, Michael B., Brennand, Kristen J.
Format: Article
Language:English
Subjects:
Autistic Disorder
Humans
Interneurons - physiology
Long QT Syndrome
Syndactyly - genetics
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Summary:Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using “assembloids” from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies. Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using “assembloids” from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2022.01.004