Cytomegalovirus is not associated with cognitive function in UK adults aged 40 to 70 years

•Cytomegalovirus has been associated with psychiatric illness and cognitive function.•Findings associating cytomegalovirus and cognition in healthy adults have been mixed.•We found no associations between cytomegalovirus and cognition in healthy UK adults.•Age, sex, and education did not interact wi...

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Bibliographic Details
Published in:Psychiatry research 2022-03, Vol.309, p.114410-114410, Article 114410
Main Authors: Gale, Shawn D., Erickson, Lance D., Brown, Bruce L., Hedges, Dawson W.
Format: Article
Language:English
Subjects:
Adult
Cognition
Cytomegalovirus
Educational Status
Humans
UK Biobank
United Kingdom - epidemiology
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Summary:•Cytomegalovirus has been associated with psychiatric illness and cognitive function.•Findings associating cytomegalovirus and cognition in healthy adults have been mixed.•We found no associations between cytomegalovirus and cognition in healthy UK adults.•Age, sex, and education did not interact with cytomegalovirus to affect cognition. Infecting much of the world's population, the herpesviridae virus cytomegalovirus has been associated with lower cognitive function in some but not all studies. In this study, we further investigate associations between cytomegalovirus and cognitive function in a community-based sample of adults aged 40 to 70 years (M = 55.3; SD = 8.1) from the United Kingdom. Adjusted multiple-regression modeling showed no significant associations between cytomegalovirus and performance on nine cognitive tasks. Further, in adjusted interaction models, age, sex, educational attainment, and income did not moderate associations between cytomegalovirus and cognitive function. In this community-based adult sample, cytomegalovirus was not associated with cognitive function.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2022.114410