High soluble HLA‐DQB2 levels in posttransplant serum are associated with kidney graft dysfunction

HLA‐DQB2 is a gene of limited polymorphism, with unknown function that presents at least two transcript variants: v1, which encodes the full‐length beta‐chain, and v2, which lacks exon 4 and could give rise to a soluble protein. We previously showed a strong correlation between high v2 expression in...

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Bibliographic Details
Published in:International journal of immunogenetics 2022-04, Vol.49 (2), p.63-69
Main Authors: Mine, Karina L, Marco, Renato, Raimundo, Tamiris R.F., Ernesto, Julia V., Medina‐Pestana, José O., Tedesco‐Silva, Hélio, Gerbase‐DeLima, Maria
Format: Article
Language:English
Subjects:
Biopsy
Cohort Studies
Donors
DQB2 rs7453920 SNP
Gene polymorphism
Glomerular filtration rate
Graft Rejection
Graft Survival
Histocompatibility antigen HLA
HLA expression
HLA‐DQB2
Humans
Kidney
kidney graft function
Kidney transplantation
Kidney Transplantation - adverse effects
Kidneys
Polymerase chain reaction
Polymorphism
posttransplant monitoring
preimplantation biopsies
Reverse transcription
Serum levels
Single-nucleotide polymorphism
soluble HLA‐DQB2
Tissue Donors
Transplants & implants
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Summary:HLA‐DQB2 is a gene of limited polymorphism, with unknown function that presents at least two transcript variants: v1, which encodes the full‐length beta‐chain, and v2, which lacks exon 4 and could give rise to a soluble protein. We previously showed a strong correlation between high v2 expression in preimplantation biopsies (PIB) of kidneys from young (18‐ to 49‐year olds) but not from old, deceased donors and 1‐year posttransplant low (estimated glomerular filtration rate 
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12569