High‐density lipoprotein lipid peroxidation as a diagnostics biomarker in coronary artery disease

This study aimed at evaluating the serum High‐density lipoprotein lipid peroxidation (HDLox) levels and their association with coronary artery disease (CAD). This case–control study comprised 572 patients with stable CAD and 281 healthy subjects with no history of cardiovascular disease (control gro...

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Bibliographic Details
Published in:BioFactors (Oxford) 2022-05, Vol.48 (3), p.634-642
Main Authors: Yazdandoust, Shima, Parizadeh, Seyyed Mohammad Reza, Ghayour‐Mobarhan, Majid, Yaghmaei, Parichehreh, Sahebkar, Amir Hossein
Format: Article
Language:English
Subjects:
antioxidant
Biomarkers
Case-Control Studies
Cholesterol, HDL
coronary artery disease
Coronary Artery Disease - diagnosis
coronary stenosis
Coronary Stenosis - complications
Coronary Stenosis - diagnosis
HDL function
high‐density lipoprotein lipid peroxidation
Humans
Lipid Peroxidation
Lipoproteins, HDL
Risk Factors
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Summary:This study aimed at evaluating the serum High‐density lipoprotein lipid peroxidation (HDLox) levels and their association with coronary artery disease (CAD). This case–control study comprised 572 patients with stable CAD and 281 healthy subjects with no history of cardiovascular disease (control group). Based on the results of coronary angiography, the patient group was divided into two groups: CAD− and CAD+. HDLox was measured using a fluorimetric method. The ability of HDLox and serum high‐density lipoprotein cholesterol (HDL‐C) to detect CAD and coronary artery stenosis ≥50% was also compared using the receiver operating characteristic (ROC) curve analysis. The CAD patients showed significantly higher serum HDLox levels, compared to the control group [1.15 (1.01–1.31) vs. 0.85 (0.62–1.06), no units, p 
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.1819