Assessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extractions

The objective of this study was to quantify intraoperative bleeding in patients with cirrhosis and correlate it with clinical characteristics and laboratory coagulation tests. A case-control study was carried out with 74 patients with cirrhosis who were submitted to preoperative coagulation tests (c...

Full description

Saved in:
Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2022-02, Vol.133 (2), p.148-155
Main Authors: Franco, Juliana Bertoldi, Andrade, Natália Silva, Bueno, Marcus Vinicius Rodrigues da Silva, Peres, Maria Paula Siqueira de Melo, Medina, Janaina B., Tenório, Jefferson da Rocha, Rech, Bruna de Oliveira, Ortega, Karem L.
Format: Article
Language:English
Subjects:
Case-Control Studies
Hemostasis
Humans
Liver Cirrhosis - complications
Liver Cirrhosis - surgery
Tooth Extraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to quantify intraoperative bleeding in patients with cirrhosis and correlate it with clinical characteristics and laboratory coagulation tests. A case-control study was carried out with 74 patients with cirrhosis who were submitted to preoperative coagulation tests (complete blood count, platelet count, prothrombin time/international normalized ratio, thrombin time, activated partial thrombin time, platelet aggregation, fibrinogen, protein C, protein S, antithrombin, and von Willebrand factor level and activity). The levels of nitrogen compounds that can affect the platelet function were determined in saliva and blood by using automated enzymatic-colorimetric assays. Patients with cirrhosis had changes in almost all coagulation tests. The average volumes of intraoperative bleeding and blood lost per minute in the study group (5.36 mL/min and 0.19 mL/min, respectively) were greater than those in the control group (3.05 mL/min and 0.11 mL/min, respectively; P < .05). In the control group, ascites (P = .012) and presence of periapical lesion (0.034) were positively correlated with bleeding (mL/min). With regard to coagulation tests and nitrogen compounds, only a positively moderate correlation with the platelet aggregation test was observed. No patients had hemorrhagic events and it was not possible to correlate a greater amount of bleeding with coagulation tests or nitrogen compounds in the study group.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2021.05.010