The significance of the SDF-1/CXCR4 signaling pathway in the normal development

Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and phys...

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Bibliographic Details
Published in:Molecular biology reports 2022-04, Vol.49 (4), p.3307-3320
Main Authors: Sadri, Farzad, Rezaei, Zohreh, Fereidouni, Mohammad
Format: Article
Language:English
Subjects:
Angiogenesis
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cell Movement - physiology
Chemokine CXCL12
Chemokine receptors
Chemokines
Chemotactic factors
CXC chemokines
CXCR4 protein
Embryogenesis
Histology
Humans
Life Sciences
Morphology
Neoplasms - metabolism
Neovascularization, Pathologic
Receptors, CXCR4 - genetics
Receptors, CXCR4 - metabolism
Review
SDF-1 protein
Signal Transduction
Tumors
Wound healing
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Summary:Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. Therefore, the current review aimed to summarize the related studies that addressed the molecular signature of the SDF-1/CXCR4 pathway and to explain how this axis is involved in normal events.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-07069-3