Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national study

Background A quarter of people with Intellectual Disability (ID) in the UK have epilepsy compared to 0.6% in the general population and die much younger. Epilepsy is associated with two-fifths of all deaths with related polypharmacy and multi-morbidity. Epilepsy research on this population has been...

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Bibliographic Details
Published in:Journal of neurology 2022-05, Vol.269 (5), p.2750-2760
Main Authors: Sun, James J., Perera, Bhathika, Henley, William, Angus-Leppan, Heather, Sawhney, Indermeet, Watkins, Lance, Purandare, Kiran N., Eyeoyibo, Mogbeyiteren, Scheepers, Mark, Lines, Geraldine, Winterhalder, Robert, Ashby, Samantha, De Silva, Ravi, Miller, Jonjo, Philpott, David E., Ashwin, Chris, Howkins, Joshua, Slater, Harriet, Medhurst, David, Shankar, Rohit
Format: Article
Language:English
Subjects:
Adult
Autism
Autism Spectrum Disorder - epidemiology
Cohort Studies
Epilepsy
Epilepsy - complications
Epilepsy - drug therapy
Epilepsy - epidemiology
Female
Genetic disorders
Humans
Intellectual disabilities
Intellectual Disability - complications
Intellectual Disability - epidemiology
Male
Medicine
Medicine & Public Health
Morbidity
Multimorbidity
Neurology
Neuroradiology
Neurosciences
Original Communication
Polypharmacy
Retrospective Studies
Risk factors
Seizures
Seizures - drug therapy
Sudden Unexpected Death in Epilepsy
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Summary:Background A quarter of people with Intellectual Disability (ID) in the UK have epilepsy compared to 0.6% in the general population and die much younger. Epilepsy is associated with two-fifths of all deaths with related polypharmacy and multi-morbidity. Epilepsy research on this population has been poor. This study describes real-world clinical and risk characteristics of a large cohort across England and Wales. Methods A retrospective multi-centre cohort study was conducted. Information on seizure characteristics, ID severity, relevant co-morbidities, psychotropic and antiseizure drugs (ASDs), SUDEP and other risk factors was collected across a year. Results Of 904 adults across 10 centres (male:female, 1.5:1), 320 (35%) had mild ID and 584 (65%) moderate-profound (M/P) ID. The mean age was 39.9 years (SD 15.0). Seizures were more frequent in M/P ID ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-021-10938-3