Pregnancy outcomes in patients with late-onset severe OHSS following different methods of ascetic fluid drainage and a comparison with non-OHSS IVF patients

Purpose In this study, we aimed to identify whether there are any differences in pregnancy outcomes in patients with severe ovarian hyperstimulation syndrome (OHSS) following the drainage of ascites by central venous catheter or paracentesis. We also aimed to identify differences in pregnancy outcom...

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Published in:Archives of gynecology and obstetrics 2022-06, Vol.305 (6), p.1587-1594
Main Authors: Ren, Yun, Li, Rong, Yang, Shuo, Yang, Rui, Song, Donghong
Format: Article
Language:English
Subjects:
Ascites
Birth rate
Birth weight
Catheters
Drainage
Endocrinology
Gynecologic Endocrinology and Reproductive Medicine
Gynecology
Human Genetics
In vitro fertilization
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pregnancy
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Summary:Purpose In this study, we aimed to identify whether there are any differences in pregnancy outcomes in patients with severe ovarian hyperstimulation syndrome (OHSS) following the drainage of ascites by central venous catheter or paracentesis. We also aimed to identify differences in pregnancy outcomes between severe OHSS patients and non-OHSS IVF patients. Methods This was a retrospective cohort analysis carried out in a university-affiliated reproductive center between 2012 and 2019 featuring 359 women with severe OHSS following ascites draining and 345 non-OHSS women (matched by age and the number of oocytes retrieved). We investigated the rates of clinical pregnancy, multiple pregnancies, miscarriage, live birth, and preterm delivery, between the two groups. Within the OHSS group (central venous catheter group vs paracentesis group), we also analyzed the odds ratios and 95% confidence intervals of clinical pregnancy. Results The rate of biochemical pregnancy loss in non-OHSS patients was significantly higher than that of severe OHSS patients (11.1% vs. 0.6%; P  
ISSN:1432-0711
0932-0067
1432-0711
DOI:10.1007/s00404-021-06326-x