Decreased gray matter volume is associated with theory of mind deficit in adolescents with schizophrenia

Schizophrenia patients often suffer from deficit in theory of mind (TOM). Prior neuroimaging studies revealed neuroimaging correlates of TOM deficit in adults with schizophrenia, neuroimaging correlates of TOM in adolescents is less well established. This study aimed to investigate gray matter volum...

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Bibliographic Details
Published in:Brain imaging and behavior 2022-06, Vol.16 (3), p.1441-1450
Main Authors: Shen, Yanmei, Gao, Xueping, Huang, Chunxiang, Luo, Xuerong, Ge, Ruiyang
Format: Article
Language:English
Subjects:
Abnormalities
Adolescent
Adolescents
Biomedical and Life Sciences
Biomedicine
Brain
Brain - diagnostic imaging
Brain - pathology
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - pathology
Cognition
Cortex (frontal)
Cortex (parietal)
Cortex (temporal)
Gray Matter - diagnostic imaging
Gray Matter - pathology
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical imaging
Mental disorders
Morphometry
Multivariate analysis
Neuroimaging
Neuropsychology
Neuroradiology
Neurosciences
Normalizing
Operculum
Original Research
Phenotypes
Psychiatry
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - pathology
Social interactions
Substantia grisea
Teenagers
Theory of Mind
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Summary:Schizophrenia patients often suffer from deficit in theory of mind (TOM). Prior neuroimaging studies revealed neuroimaging correlates of TOM deficit in adults with schizophrenia, neuroimaging correlates of TOM in adolescents is less well established. This study aimed to investigate gray matter volume (GMV) abnormalities and TOM deficits in schizophrenic adolescents, and examine the relationship between them. Twenty adolescent schizophrenic patients and 25 age, sex-matched healthy controls underwent T1-weighted magnetic resonance imaging (MRI) scans, and were examined for TOM based on the Reading the Mind in the Eyes test (RMET). Univariate voxel-based morphometry (VBM) and multivariate source-based morphometry (SBM) were employed to examine alterations of two GMV phenotypes in schizophrenic adolescents: voxel-wise GMV and covarying structural brain patterns (SBPs). Compared with controls, our results revealed a significant deficit in RMET performance of the patients, Voxel-wise VBM analysis revealed that patients exhibited decreased GMV in bilateral insula, orbitofrontal cortex, and right rolandic operculum, and GMV of these brain regions were positively correlated with RMET performance. Multivariate SBM analysis identified a significantly different between-group SBP comprising of bilateral insula and inferior frontal cortex, bilateral superior temporal cortex, and bilateral lateral parietal cortex and right rolandic operculum. The loading scores of this SBP was positively correlated with RMET performance. This study revealed impairment of TOM ability in schizophrenic adolescents and revealed an association between TOM deficit and decreased GMV in regions which are crucial for social cognition, thereby provided insight and possible target regions for understanding the neural pathology and normalizing TOM deficit in adolescent schizophrenia patients.
ISSN:1931-7557
1931-7565
DOI:10.1007/s11682-021-00591-9