Optofluidic systems enabling detection in real samples: A review

Optofluidics, understood as the synergistic combination between microfluidics and photonics, has been at the forefront of the scientific research due to its outmatching properties: on the one hand, microfluidics allows the handling of minute amounts of liquid samples at the microscale. On the other...

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Bibliographic Details
Published in:Analytica chimica acta 2022-02, Vol.1192, p.339307-339307, Article 339307
Main Authors: Fernandez-Cuesta, Irene, Llobera, Andreu, Ramos-Payán, María
Format: Article
Language:English
Subjects:
Biofluids
DNA detection
Fresh water
Heavy metals
Ions
Lab-on-a-chip
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques
Microfluidics
Optics and Photonics
Optofluidics
Pathogen detection
Protein biomarker detection
Real samples
Water samples
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Summary:Optofluidics, understood as the synergistic combination between microfluidics and photonics, has been at the forefront of the scientific research due to its outmatching properties: on the one hand, microfluidics allows the handling of minute amounts of liquid samples at the microscale. On the other hand, photonics has proved to outmatch other detection methods (e.g. electrochemistry) in terms of sensitivity and selectivity. From the initial single analyte or spiked samples, currently the technology is mature enough for selective detection of a variety of analytes in raw, complex liquid samples. This will pave the way for the applicability of optofluidic devices for applications in the field or at the point of care. Here, we will revisit the current state of the art of optofluidic and photonic lab-on-a-chip systems for the analysis of real and biologically relevant samples: body fluids and water. [Display omitted] •Review on optofluidic and photonic lab-on-a-chip devices for analyzing real samples.•Optofluidics merges handling minute liquid amounts and the sensitivity of photonics.•We focus on works on biologically relevant samples, body fluids and water.•In biosamples/body fluids: cells, pathogens, protein biomarkers and nucleic acids.•In water: bacteria/toxins, endocrine disruptors, organic compounds and ions.
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2021.339307