In Vivo Comparison of Micro-Balloon Interventions (MBI) Advantage: A Retrospective Cohort Study of DEB-TACE Versus b-TACE and of SIRT Versus b-SIRT

Purpose The purpose of this study was to evaluate in vivo the role of the micro-balloon by comparing trans-arterial chemoembolization (DEB-TACE) and selective internal radiotherapy (SIRT) procedures performed with and without balloon micro-catheter (b-DEB-TACE and DEB-TACE/SIRT and b-SIRT) for the t...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2022-03, Vol.45 (3), p.306-314
Main Authors: Lucatelli, Pierleone, De Rubeis, Gianluca, Trobiani, Claudio, Ungania, Sara, Rocco, Bianca, De Gyurgyokai, Simone Zilahi, Masi, Marica, Pecorella, Irene, Cappelli, Federico, Lai, Quirino, Catalano, Carlo, Vallati, Giulio
Format: Article
Language:English
Subjects:
Beads
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Cardiology
Catheters
Chemoembolization
Chemoembolization, Therapeutic - methods
Cohort analysis
Computed tomography
Dosimeters
Dosimetry
Drug dosages
Embolization
Hepatocellular carcinoma
Humans
Imaging
In vivo methods and tests
Interventional Oncology
Liver
Liver cancer
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Liver transplantation
Localization
Medical instruments
Medicine
Medicine & Public Health
Microballoons
Microspheres
Nuclear Medicine
Patients
Photon emission
Radiation therapy
Radiology
Retrospective Studies
Scientific Paper (other)
Signal to noise ratio
Subgroups
Transplantation
Treatment Outcome
Two dimensional analysis
Ultrasound
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Summary:Purpose The purpose of this study was to evaluate in vivo the role of the micro-balloon by comparing trans-arterial chemoembolization (DEB-TACE) and selective internal radiotherapy (SIRT) procedures performed with and without balloon micro-catheter (b-DEB-TACE and DEB-TACE/SIRT and b-SIRT) for the treatment of hepatocellular carcinoma (HCC). Methods The impact of a balloon micro-catheter on trans-arterial loco-regional treatment was analyzed using non-enhanced post-procedural cone-beam CT (Ne-CBCT) by comparing the attenuation values in the embolized area and the surrounding liver tissue before and after DEB-TACE versus b-DEB-TACE and by comparing 2D/3D dosimetry in single-photon emission computed tomography after SIRT versus b-SIRT, and by comparing the histological count of the beads following orthotopic liver transplantation in the DEB-TACE versus b-DEB-TACE subgroup. Results We treated 84 HCC patients using trans-arterial loco-regional therapy. Fifty-three patients (26 DEB-TACE and 27 b-DEB-TACE) were analyzed in the TACE group. Contrast, signal-to-noise ratio, and contrast-to-noise ratio were all significantly higher in b-DEB-TACE subgroup than DEB-TACE (182.33 HU [CI95% 160.3–273.5] vs. 124 HU [CI95% 80.6–163.6]; 8.3 [CI95% 5.7–10.1] vs. 4.5 [CI95% 3.7–6.0]; 6.9 [CI95% 4.3–7.8] vs. 3.1 [CI95% 2.2–5.0] p  
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-021-03035-5