Up-regulated serum levels of TAM receptor tyrosine kinases in a group of Egyptian autistic children

TAM receptor family belongs to receptor tyrosine kinases (TAMRTKs). It includes three receptors; Tyro-3, Axl and Mer. TAMRTKs has a great role in resolution of inflammation due to their role in clearance of apoptotic cells by macrophages. Dysregulated TAM signaling pathways are associated with many...

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Bibliographic Details
Published in:Journal of neuroimmunology 2022-03, Vol.364, p.577811-577811, Article 577811
Main Authors: Mostafa, Gehan Ahmed, ElGebaly, Howida Hosny, Shehab, Abeer Al Sayed, Mohamed, Marwa Abd El Hamed
Format: Article
Language:English
Subjects:
Autism
Autistic Disorder - blood
Autistic Disorder - enzymology
Axl,CARS
Biomarkers - blood
Child
Child, Preschool
Cross-Sectional Studies
Egypt
Female
Humans
Male
Mer
Receptor Protein-Tyrosine Kinases - blood
Receptor tyrosine kinases
TAMRTKs
Tyro-3
Up-Regulation
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Summary:TAM receptor family belongs to receptor tyrosine kinases (TAMRTKs). It includes three receptors; Tyro-3, Axl and Mer. TAMRTKs has a great role in resolution of inflammation due to their role in clearance of apoptotic cells by macrophages. Dysregulated TAM signaling pathways are associated with many autoimmune diseases and chronic inflammatory disorders. Autism may be an autoimmune disease in some patients. This work was the first study that investigated serum levels of the soluble ectodomain shed TAMRTKs in a group of autistic children. Serum levels of TAMRTKs were measured by ELISA in 30 autistic children aged between 3.5 and 11 years and 30 age and sex-matched healthy control children. Serum levels of TAMRTKs were significantly higher in autistic children than healthy control children (P 
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2022.577811