Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites

The study consists of three parts. In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out. The beads were formed from CoFe 2 O 4 /chitosan and MnFe 2 O 4 /chitosan. TGA and SEM we...

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Bibliographic Details
Published in:Preparative biochemistry & biotechnology 2022, Vol.52 (9), p.979-989
Main Authors: Yildirim, Ayşegül, Ispirli Doğaç, Yasemin
Format: Article
Language:English
Subjects:
5-Fluorouracil
Beads
Chitosan
Cobalt ferrites
Controlled release
Core-shell
Drug delivery
Drug delivery systems
magnetic composite
Magnetic materials
magnetic nanoparticles
Mathematical models
Nanoparticles
pH effects
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Summary:The study consists of three parts. In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out. The beads were formed from CoFe 2 O 4 /chitosan and MnFe 2 O 4 /chitosan. TGA and SEM were used for the characterization of core-shell materials. In the second part, swelling experiments of magnetic beads were performed. In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined. Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling. Both prepared systems were found to be suitable for controlled release for 5-Fluorouracil.
ISSN:1082-6068
1532-2297
DOI:10.1080/10826068.2021.2021234