Cadinane sesquiterpenoids from the fungus Antrodiella albocinnamomea and their inhibitory activity against nitric oxide production

Seven previously undescribed cadinane sesquiterpenoids, albocinnamins A‒G, were isolated from the fungus Antrodiella albocinnamomea. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic methods, as well as single crystal X-ray diffraction. Cadinane se...

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Published in:Phytochemistry (Oxford) 2022-04, Vol.196, p.113081-113081, Article 113081
Main Authors: Yu, Wei-Wei, Ma, Jin-Tao, He, Juan, Li, Zheng-Hui, Liu, Ji-Kai, Feng, Tao
Format: Article
Language:English
Subjects:
Albocinnamins A‒G
Antrodiella albocinnamomea
Cadinane sesquiterpenoids
Molecular Structure
Nitric Oxide
NO production Inhibition
Polycyclic Sesquiterpenes
Polyporaceae
Polyporales
Sesquiterpenes - chemistry
Structural elucidation
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Summary:Seven previously undescribed cadinane sesquiterpenoids, albocinnamins A‒G, were isolated from the fungus Antrodiella albocinnamomea. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic methods, as well as single crystal X-ray diffraction. Cadinane sesquiterpenoids were reported from A. albocinnamomea for the first time. All of these sesquiterpenoids possess an unusual ether ring with minor modifications. Albocinnamins D and G showed certain inhibitory activities against nitric oxide production in LPS-activated RAW264.7 macrophages with IC50 values of 26.1 and 19.2 μM, respectively. [Display omitted] •Seven undescribed sesquiterpenoids were isolated from Antrodiella albocinnamomea.•Cadinane sesquiterpenoids were reported from A. albocinnamomea for the first time.•The structures with absolute configurations were established.•Two compounds exhibited inhibitory activities against nitric oxide production.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2021.113081