A much needed metric: Defining reliable and statistically meaningful change of the oral version Symbol Digit Modalities Test (SDMT)

•Processing speed is the most common cognitive disturbance in multiple sclerosis.•The Symbol Digit Modalities Test (SDMT), a simple measure of processing speed has been deemed the most sensitive measure to MS-related cognitive dysfunction.•However, defining what a clinically and statistically meanin...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis and related disorders 2022-01, Vol.57, p.103405-103405, Article 103405
Main Authors: Strober, L.B., Bruce, J.M., Arnett, P.A., Alschuler, K.N., DeLuca, J., Chiaravalloti, N., Lebkuecher, A., Di Benedetto, M., Cozart, J., Thelen, J., Cadden, M., Guty, E., Román, C.A.F.
Format: Article
Language:English
Subjects:
Humans
Multiple Sclerosis
Neuropsychological Tests
Processing speed
Reliable change indices
Reproducibility of Results
Symbol digit modalities test
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Processing speed is the most common cognitive disturbance in multiple sclerosis.•The Symbol Digit Modalities Test (SDMT), a simple measure of processing speed has been deemed the most sensitive measure to MS-related cognitive dysfunction.•However, defining what a clinically and statistically meaningful change on the SDMT has not been established.•The present investigation was conducted to develop reliable change indices and standardized regression based norms to better assist practitioners and researchers in establishing what is a statistically meaningful change on the SDMT. : The Symbol Digit Modalities Test (SDMT) has been recommended for use in clinical trials and outcome studies to monitor cognitive change. However, defining what is a meaningful change has been elusive for several years. : The present investigation aimed to develop methods for assessing individual-level statistically significant change on the SDMT - reliable change indices (RCIs) and standardized regression-based (SRB) equations. : A total of 219 healthy individuals completed the oral version SDMT at baseline, 6-month and 1-year follow-up. : The SDMT demonstrated high reliability across all time points (r's = 0.83 to 0.86). Reliable change scores of 7, 8, and 10 points for the 6-month intervals represented statistically meaningful change at the 0.70, 0.80, and 0.90 confidence intervals, respectively. Over 1-year, a difference of 8, 10, and 12 was statistically meaningful at the 0.70, 0.80, and 0.90 confidence intervals, respectively. SRB equations are also provided taking into account additional factors found to be predictive of SDMT scores over time. : Clinicians frequently denote a decline of 4 points on the SDMT as meaningful. Results in this large normative sample show that higher cut-points are needed to demonstrate statistically significant decline at the individual level. RCIs are provided for 6 month and one year assessment, which is typical in clinical practice and trials. SRB equations are also provided for use when applicable and may provide a more precise assessment of meaningful change.
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2021.103405