Increased selenium concentration in the synthesis of CdSe magic‐sized quantum dots affects how the brain responds to oxidative stress

CdSe magic‐sized quantum dots (MSQDs) have been widely used as fluorescent probes in biological systems due to their excellent optical properties with a broader fluorescence spectrum and stable luminescence in biological media. However, they can be cytotoxic and alter the redox balance depending on...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2022-05, Vol.110 (5), p.1140-1150
Main Authors: Vilela, Danielle Diniz, Justino, Allisson Benatti, Caixeta, Douglas Carvalho, Souza, Adriele Vieira, Teixeira, Renata Roland, Franco, Rodrigo Rodrigues, Saraiva, André Lopes, Fonseca, Belchiolina Beatriz, Dantas, Noelio Oliveira, Silva, Anielle Christine Almeida, Espindola, Foued Salmen
Format: Article
Language:English
Subjects:
Animals
antioxidant enzymes
Antioxidants
Antioxidants - pharmacology
Biomedical materials
Brain
Brain - metabolism
Cadmium
Cadmium - pharmacology
Cadmium Compounds - pharmacology
cadmium selenide
Cadmium selenides
Catalase
Chick Embryo
Chorioallantoic membrane
Cytotoxicity
Embryos
Fluorescence
Fluorescent indicators
Glutathione
Glutathione peroxidase
Glutathione reductase
Lipid peroxidation
Lipids
magic‐sized quantum dots
Materials research
Materials science
nanobiotechnology
Nanomaterials
Nanotechnology
Optical properties
Oxidative Stress
Peroxidase
Peroxidation
Quantum Dots
Reductases
Selenium
Selenium - pharmacology
Selenium Compounds - pharmacology
Superoxide Dismutase
Surface defects
Synthesis
Toxicity
Vascularization
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Summary:CdSe magic‐sized quantum dots (MSQDs) have been widely used as fluorescent probes in biological systems due to their excellent optical properties with a broader fluorescence spectrum and stable luminescence in biological media. However, they can be cytotoxic and alter the redox balance depending on the amounts of Cd2+ adsorbed on their surface. Thus, the present study aimed to evaluate whether increases in selenium concentration in the synthesis of CdSe‐MSQDs decrease the oxidative stress caused by Cd2+‐based quantum dots. CdSe‐MSQDs synthesized with different concentrations of selenium were investigated against oxidative stress in the brain of chicken embryos by examining total antioxidant capacity, lipid peroxidation, thiol, and glutathione contents, as well as the activities of glutathione peroxidase, superoxide dismutase (SOD), catalase (CAT), and glutathione reductase. In addition, the vascularization of the chorioallantoic membrane (CAM) analysis was performed. Higher selenium concentrations alter the surface defect levels (decrease free Cd2+) and controlled the oxidative effects of CdSe‐MSQDs by reducing the lipid peroxidation, restoring the glutathione defense system and the antioxidant enzymes SOD and CAT, and maintaining the vascular density of the CAM. The current findings reinforce the study of the effects of the presence of Cd2+ ions on the surface of quantum dots, changing toxicity, and aiming interesting strategies of nanomaterials in biological systems.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.34988