The Impact of Alcohol-Induced Dysbiosis on Diseases and Disorders of the Central Nervous System

The human digestive tract contains a diverse and abundant microbiota that is important for health. Excessive alcohol use can disrupt the balance of these microbes (known as dysbiosis), leading to elevated blood endotoxin levels and systemic inflammation. Using QIAGEN Ingenuity Pathway Analysis (IPA)...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2022-06, Vol.17 (1-2), p.131-151
Main Authors: Liu, Xiangqian, Vigorito, Michael, Huang, Wenfei, Khan, Mohammed A. S., Chang, Sulie L.
Format: Article
Language:English
Subjects:
Addictions
Alcohol use
Alzheimer's disease
Bacteria
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central Nervous System
Cytokines
Homeostasis
Human body
Humans
Immune system
Immunology
Inflammation
Invited Review
Mental disorders
Metabolism
Metabolites
Microbiota
Microorganisms
Nervous system
Neurodegeneration
Neurodegenerative Diseases - chemically induced
Neurosciences
Parkinson's disease
Pharmacology
Pharmacology/Toxicology
Virology
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Summary:The human digestive tract contains a diverse and abundant microbiota that is important for health. Excessive alcohol use can disrupt the balance of these microbes (known as dysbiosis), leading to elevated blood endotoxin levels and systemic inflammation. Using QIAGEN Ingenuity Pathway Analysis (IPA) bioinformatics tool, we have confirmed that peripheral endotoxin (lipopolysaccharide) mediates various cytokines to enhance the neuroinflammation signaling pathway. The literature has identified alcohol-mediated neuroinflammation as a possible risk factor for the onset and progression of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), and psychiatric disorders such as addiction to alcohol and other drugs. In this review, we discuss alcohol-use-induced dysbiosis in the gut and other body parts as a causal factor in the progression of Central Nervous System (CNS) diseases including neurodegenerative disease and possibly alcohol use disorder. Graphical Abstract
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-021-10033-4