Combination of eudragit EPO with poloxamers for improved solubility and dissolution of Zafirlukast: An evaluation of solid dispersion formulations

This study investigated the effect of solid dispersions (SD) on solubility and release of Zafirlukast (ZA) by physical mixture (PM), solvent evaporation (SE) and kneading method (KM) with Eudragit EPO (EPO) as binary component and Poloxamer 188 (P188) and Poloxamer 407 (P407) as ternary components....

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-09, Vol.34 (5(Supplementary)), p.1923-1928
Main Authors: Masood, Zeeshan, Tayyab Ansari, Muhammad, Afzal, Samina
Format: Article
Language:English
Subjects:
Drug Carriers
Drug Compounding
Drug Liberation
Excipients - chemistry
Indoles - administration & dosage
Indoles - chemistry
Leukotriene Antagonists - administration & dosage
Leukotriene Antagonists - chemistry
Phenylcarbamates - administration & dosage
Phenylcarbamates - chemistry
Poloxamer - chemistry
Polymethacrylic Acids - chemistry
Solubility
Sulfonamides - administration & dosage
Sulfonamides - chemistry
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Summary:This study investigated the effect of solid dispersions (SD) on solubility and release of Zafirlukast (ZA) by physical mixture (PM), solvent evaporation (SE) and kneading method (KM) with Eudragit EPO (EPO) as binary component and Poloxamer 188 (P188) and Poloxamer 407 (P407) as ternary components. The binary and ternary systems caused an increase of 322 folds and 356 folds in aqueous solubility of ZA, respectively. Formulations were characterized for solubility, FTIR, PXRD, DSC, SEM and dissolution studies. P407 was found to be an excellent solubility booster in combination with EPO. It was concluded that solubility and dissolution rate of ZA increased significantly when SD of the ZA was prepared by solvent evaporation method (1:7 ratio) using 15% P407 as ternary component.
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.5.SUP.1923-1928.1