Loading…

The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery

Purposes The effects of preoperative statin treatment on acute kidney injury (AKI) remain controversial, and current clinical evidence regarding statin use in the elderly undergoing valve replacement surgery (VRS) is insufficient. The present study aimed to investigate the association between preope...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 2022-03, Vol.78 (3), p.505-512
Main Authors: Fu, Bing-qi, Wei, Xue-biao, Su, Zedazhong, Lin, Ying-wen, Ke, Zu-hui, Tan, Tong, Chen, Ji-yan, Wang, Shou-hong, Yu, Dan-qing
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purposes The effects of preoperative statin treatment on acute kidney injury (AKI) remain controversial, and current clinical evidence regarding statin use in the elderly undergoing valve replacement surgery (VRS) is insufficient. The present study aimed to investigate the association between preoperative statin treatment and AKI after VRS in the elderly. Methods Three thousand seven hundred ninety-one elderly patients (≥ 60 years) undergoing VRS were included in this study and divided into 2 groups, according to the receipt of statin treatment before the operation: statin users ( n  = 894) and non-users ( n  = 2897). We determined the associations between statin use, AKI, and other adverse events using a multivariate model and propensity score-matched analysis. Results After propensity score-matched analysis, there was no difference between statin users and non-users in regard to postoperative AKI (72.5% vs. 72.4%, p  = 0.954), in-hospital death (5.7% vs. 5.1%, p  = 0.650) and 1-year mortality (log-rank = 0, p  = 0.986). The multivariate analysis showed that statin use was not an independent risk factor for postoperative AKI (OR = 0.97, 95% CI: 0.90–1.17, p  = 0.733), in-hospital mortality (OR = 1.12, 95% CI: 0.75–1.68, p  = 0.568), or 1-year mortality (HR = 0.95, 95% CI: 0.70–1.28, p  = 0.715). Conclusion Preoperative statin treatment did not significantly affect the risk of AKI among elderly patients undergoing VRS.
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-021-03252-4