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The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery
Purposes The effects of preoperative statin treatment on acute kidney injury (AKI) remain controversial, and current clinical evidence regarding statin use in the elderly undergoing valve replacement surgery (VRS) is insufficient. The present study aimed to investigate the association between preope...
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Published in: | European journal of clinical pharmacology 2022-03, Vol.78 (3), p.505-512 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Purposes
The effects of preoperative statin treatment on acute kidney injury (AKI) remain controversial, and current clinical evidence regarding statin use in the elderly undergoing valve replacement surgery (VRS) is insufficient. The present study aimed to investigate the association between preoperative statin treatment and AKI after VRS in the elderly.
Methods
Three thousand seven hundred ninety-one elderly patients (≥ 60 years) undergoing VRS were included in this study and divided into 2 groups, according to the receipt of statin treatment before the operation: statin users (
n
= 894) and non-users (
n
= 2897). We determined the associations between statin use, AKI, and other adverse events using a multivariate model and propensity score-matched analysis.
Results
After propensity score-matched analysis, there was no difference between statin users and non-users in regard to postoperative AKI (72.5% vs. 72.4%,
p
= 0.954), in-hospital death (5.7% vs. 5.1%,
p
= 0.650) and 1-year mortality (log-rank = 0,
p
= 0.986). The multivariate analysis showed that statin use was not an independent risk factor for postoperative AKI (OR = 0.97, 95% CI: 0.90–1.17,
p
= 0.733), in-hospital mortality (OR = 1.12, 95% CI: 0.75–1.68,
p
= 0.568), or 1-year mortality (HR = 0.95, 95% CI: 0.70–1.28,
p
= 0.715).
Conclusion
Preoperative statin treatment did not significantly affect the risk of AKI among elderly patients undergoing VRS. |
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ISSN: | 0031-6970 1432-1041 |
DOI: | 10.1007/s00228-021-03252-4 |