Review: Outcome measures in calcium pyrophosphate deposition

This review highlights outcomes for patients with calcium pyrophosphate deposition (CPPD) reported in prior studies and underscores challenges to assessing outcomes of this condition. Prior clinical studies of interventions for CPPD focused on joint damage and calcification on imaging tests, joint p...

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Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2021-12, Vol.35 (4), p.101724-101724, Article 101724
Main Authors: Cai, Ken, Tedeschi, Sara K.
Format: Article
Language:English
Subjects:
Calcium Pyrophosphate
Calcium pyrophosphate deposition disease
Chondrocalcinosis - diagnostic imaging
CPPD
Humans
Outcome Assessment, Health Care
Outcome measures
Pseudogout
Reproducibility of Results
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Summary:This review highlights outcomes for patients with calcium pyrophosphate deposition (CPPD) reported in prior studies and underscores challenges to assessing outcomes of this condition. Prior clinical studies of interventions for CPPD focused on joint damage and calcification on imaging tests, joint pain, swelling, and inflammatory biomarkers. Qualitative interviews with patients with CPPD and healthcare providers additionally identified flares, overall function, and use of analgesic medications as important outcomes. Imaging evidence of joint damage and calcification is likely to be outcomes in future clinical studies of CPPD, though reliability and sensitivity to change in CPPD require further testing for several imaging modalities. Challenges to outcome measurement in CPPD include questions of attribution of signs and symptoms to CPPD versus co-existing forms of arthritis, lack of therapies to prevent or dissolve calcium pyrophosphate crystal deposition, absence of validated patient- or physician-reported CPPD outcome measures, and scarcity of large cohorts in which to study outcomes of different clinical presentations of CPPD.
ISSN:1521-6942
1532-1770
DOI:10.1016/j.berh.2021.101724