Intellectual development of patients with biliary atresia who underwent living donor liver transplantation in infancy

Background The impact of pediatric liver transplantation on intellectual development has yet to be determined. We investigated the intellectual outcomes of school-aged patients after living donor liver transplantation for biliary atresia in infancy. Methods The Wechsler Intelligence Scale for Childr...

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Published in:Pediatric surgery international 2022-02, Vol.38 (2), p.201-208
Main Authors: Kawabata, Seiichi, Sakamoto, Rieko, Uto, Keiichi, Irie, Tomoaki, Kadohisa, Masashi, Shimata, Keita, Narita, Yasuko, Isono, Kaori, Honda, Masaki, Hayashida, Shintaro, Ohya, Yuki, Yamamoto, Hidekazu, Yamamoto, Hirotoshi, Nakano, Miwako, Sugawara, Yasuhiko, Inomata, Yukihiro, Hibi, Taizo
Format: Article
Language:English
Subjects:
Biliary Atresia - surgery
Caregivers
Child
Cognition & reasoning
Families & family life
Humans
Liver diseases
Liver Transplantation
Liver transplants
Living Donors
Logistic Models
Medicine
Medicine & Public Health
Metabolism
Original Article
Patients
Pediatric Surgery
Pediatrics
Population
Postoperative Period
Quality of life
Regression analysis
Surgery
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Summary:Background The impact of pediatric liver transplantation on intellectual development has yet to be determined. We investigated the intellectual outcomes of school-aged patients after living donor liver transplantation for biliary atresia in infancy. Methods The Wechsler Intelligence Scale for Children—fourth edition test was administered to 20 patients who survived ≥ 5 years after living donor liver transplantation. Borderline full scale intelligence quotient was defined as ≤ 85. Pre-, peri-, and postoperative data were compared between patients with > 85 and ≤ 85 to identify predictive factors of borderline performance. Results The one-sample t test demonstrated that the mean full scale intelligence quotient of patients after transplantation for biliary atresia was significantly lower than that of the general population (91.8 vs. 100.0, p  = 0.026) and 7 (35%) were classified as intellectual borderline functioning. Multivariable logistic regression models were unable to identify any factors predictive of full scale intelligence quotients of ≤ 85. Conclusion This is the first study to indicate that the mean full scale intelligence quotient among school-aged patients who underwent living donor liver transplantation for biliary atresia in infancy is significantly lower than that of the general population.
ISSN:0179-0358
1437-9813
DOI:10.1007/s00383-021-05042-6