Origins and evolution of extreme life span in Pacific Ocean rockfishes

Pacific Ocean rockfishes (genus ) exhibit extreme variation in life span, with some species being among the most long-lived extant vertebrates. We de novo assembled the genomes of 88 rockfish species and from these identified repeated signatures of positive selection in DNA repair pathways in long-l...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2021-11, Vol.374 (6569), p.842-847
Main Authors: Kolora, Sree Rohit Raj, Owens, Gregory L, Vazquez, Juan Manuel, Stubbs, Alexander, Chatla, Kamalakar, Jainese, Conner, Seeto, Katelin, McCrea, Merit, Sandel, Michael W, Vianna, Juliana A, Maslenikov, Katherine, Bachtrog, Doris, Orr, James W, Love, Milton, Sudmant, Peter H
Format: Article
Language:English
Subjects:
Adaptation
Aging
Animals
Biographies
Biological Evolution
Butyrophilin
Butyrophilins - genetics
Copy number
CpG islands
Deoxyribonucleic acid
DNA
DNA repair
DNA Repair - genetics
Evolution
Gene Dosage
Gene sequencing
Genetic analysis
Genetic diversity
Genetic Pleiotropy
Genetic Speciation
Genetic Variation
Genetics
Genome
Genomes
Genomic analysis
High-Throughput Nucleotide Sequencing
Immunomodulation - genetics
Insulin
Life history
Life History Traits
Life span
Longevity
Longevity - genetics
Mutation
Pacific Ocean
Perciformes - genetics
Perciformes - physiology
Phylogeny
Positive selection
Repair
Scorpaenidae
Selection, Genetic
Species
Vertebrates
Whole Genome Sequencing
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Summary:Pacific Ocean rockfishes (genus ) exhibit extreme variation in life span, with some species being among the most long-lived extant vertebrates. We de novo assembled the genomes of 88 rockfish species and from these identified repeated signatures of positive selection in DNA repair pathways in long-lived taxa and 137 longevity-associated genes with direct effects on life span through insulin signaling and with pleiotropic effects through size and environmental adaptations. A genome-wide screen of structural variation reveals copy number expansions in the immune modulatory butyrophilin gene family in long-lived species. The evolution of different rockfish life histories is coupled to genetic diversity and reshapes the mutational spectrum driving segregating CpG→TpG variants in long-lived species. These analyses highlight the genetic innovations that underlie life history trait adaptations and, in turn, how they shape genomic diversity.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.abg5332