Chronic Kidney Disease Risk Profile in Renal Donors in Aguascalientes, Mexico: A Retrospective Cohort Study

In the last decade, kidney donation has been recognized as a risk factor for end-stage renal disease (ESRD). ESRD risk calculators have been recently perfected in North American populations. In Mexico, the rates of overweight, obesity, and diabetes mellitus (DM) are among the highest worldwide; neve...

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Published in:Transplantation proceedings 2022-09, Vol.54 (7), p.1701-1706
Main Authors: Reza-Escalera, Ana Lilian, Tiscareño-Gutiérrez, Maria Teresa, Ovalle-Robles, Itzel, Macias-Guzmán, Mariana Jocelyn, Garcia-Díaz, Andrea Lucia, Gutierrez-Peña, Cesar Mauricio, Chew-Wong, Alfredo, Ricalde-Ríos, Guadalupe, Romo-Franco, Luis, Reyes-Acevedo, Rafael, Galvan-Guerra, Elva, Lagunas-Rodríguez, Ana Betsaida, Delgado-Beltran, Mónica Ivette, Rojas-Terán, Jaime Froylan, Delgadillo-Castañeda, Rodolfo, Macias-Diaz, Dulce Maria, Alberu-Gomez, Josefina, Arreola-Guerra, Jose Manuel
Format: Article
Language:English
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Summary:In the last decade, kidney donation has been recognized as a risk factor for end-stage renal disease (ESRD). ESRD risk calculators have been recently perfected in North American populations. In Mexico, the rates of overweight, obesity, and diabetes mellitus (DM) are among the highest worldwide; nevertheless, most kidney transplants are obtained from living donors. This study aims to describe the risk profile for chronic kidney disease (CKD) development in kidney donors in a highly active transplant center in Central Mexico. We conducted a retrospective, observational, descriptive cohort study of kidney donors followed at the Hospital Centenario Miguel Hidalgo (CHMH). We used the pretransplant CKD risk calculator at 15 years and over a lifetime (www.transplantmodels.com/esrdrisk). Aside from the calculator of kidney failure risk, we also used the calculator for postdonation CKD risk (www.transplantmodels.com/donesrd/). Factors associated with a glomerular filtration rate (GFR) 0.1%, and only 1 patient had a risk >1%. The lifetime ESRD risk was 0.62% (±0.5); 15% had a risk >1%, and the greatest risk was 3.5%. The median of patients at risk of developing postdonation ESRD was 1 in 10,000 donors (0.6-1.5) at 5 years, 5.7 in 10,000 donors (3.5-8.8) at 10 years, 15 in 10,000 donors (9.1-23.2) at 15 years, and 31 in 10,000 donors (18.9-47.7) at 20 years. During the follow-up period, 52 patients developed a GFR of
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2021.09.036