Impact of COVID-19 Infection on Neonatal Birth Outcomes

Abstract Introduction There is limited data on newborns born to mothers with COVID-19 infection. This multicenter cohort study aimed to investigate the clinical characteristics and outcomes of neonates born to mothers with and without COVID-19 infection to fill a gap in the literature review. Method...

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Published in:Journal of tropical pediatrics (1980) 2021-10, Vol.67 (5)
Main Authors: Vizheh, Maryam, Allahdadian, Maryam, Muhidin, Salut, Valiani, Mahboubeh, Bagheri, Khadijeh, Borandegi, Forogh, Ghasimi, Golnaz
Format: Article
Language:English
Subjects:
Cohort Studies
COVID-19
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Outcome - epidemiology
Premature Birth
Retrospective Studies
SARS-CoV-2
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Summary:Abstract Introduction There is limited data on newborns born to mothers with COVID-19 infection. This multicenter cohort study aimed to investigate the clinical characteristics and outcomes of neonates born to mothers with and without COVID-19 infection to fill a gap in the literature review. Methods The medical records of all neonates in Isfahan, Iran, between October 2020 and March 2021, were retrospectively reviewed. Results Among the 600 neonates in this study, 255 (42.5%) were in the infected group and 345 (57.5%) were assigned to the control group as they were born to non-infected mothers. In the infected group, sepsis, fever and pneumothorax were detected in 3 (1.2%), 3 (1.2%) and 4 (1.6%) neonates, respectively, compared with no case in the control group. In the infected group, neonatal respiratory distress (NRDS) (32, 12.5%) was significantly higher than the control group (27, 10.6%). Asphyxia in the infected group was 22(6.4%), compared with 19 (5.5%), in the control group. Preterm labor (PTL) (55, 21.65%), premature rupture of membranes (PROMs) (24, 9.4%) and intra-uterine growth retardation (IUGR) (15, 5.9%) were significantly higher in women with COVID-19 (45, 13.0%, 4, 1.2% and 7, 2.0%, respectively). Low birth weight (LBW) accounted for 42 (16.5%) neonates in the infected group and 25 (7.2%) in the control group (p < 0.05). Of the 255 neonates born to infected mothers, 38 (14.9%) were admitted to the Neonatal Intensive Care Unit (NICU), compared with 31 out of 345 (9.0%) in the control group (p < 0.05). RT-PCR test results were positive in two newborns (0.8%), one of whom died of necrotizing enterocolitis. Conclusion As a result of maternal COVID-19 infections, neonates experienced higher rates of sepsis, fever, pneumothorax, asphyxia and NRDS in addition to PTL, PROMs, IUGR, and LBW. Lay Summary Contradictory results have been reported on the impact of COVID-19 infection on neonatal outcomes. We conducted a review of 600 cases of neonates, with 255 (42.5%) in the COVID-19 infected and 345 (57.5%) in the control group. The results indicated that neonates born to women with COVID-19 showed higher rates of sepsis, fever, pneumothorax, asphyxia and neonatal respiratory distress in addition to preterm labor, premature rupture of membranes, intra-uterin growth retardation and low birth weight.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmab094