Physical activity level (PAL) and risk factors of cardiovascular disease in the MASHAD study cohort

The relationship between physical activity levels (PAL) and the presence of cardiovascular disease (CVD) risk factors such as anthropometric and biochemical indices and heat shock proteins 27 antibody (anti-HSP-27) concentration, and serum inflammatory markers, was investigated in the MASHAD cohort...

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Published in:Diabetes & metabolic syndrome clinical research & reviews 2021-11, Vol.15 (6), p.102316-102316, Article 102316
Main Authors: Sadabadi, Fatemeh, Zirak, Roshanak Ghaffarian, Ghazizadeh, Hamideh, Mohadese rohban, Rastgar Moghadam, Azam, Mouhebati, Mohsen, Ehyaei, Sahar, Fadihe, Fattaneh Tavassoli, Zare-Feyzabadi, Reza, Ferns, Gordon A., Ghayour-Mobarhan, Majid
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Biomarkers - blood
Blood Pressure - physiology
Body Mass Index
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Cohort Studies
Exercise - physiology
Female
Heat shock proteins 27 antibody
Heat-Shock Proteins - blood
Humans
Iran - epidemiology
Male
Middle Aged
Molecular Chaperones - blood
Physical activity level
Risk Factors
Waist-Hip Ratio - methods
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Summary:The relationship between physical activity levels (PAL) and the presence of cardiovascular disease (CVD) risk factors such as anthropometric and biochemical indices and heat shock proteins 27 antibody (anti-HSP-27) concentration, and serum inflammatory markers, was investigated in the MASHAD cohort study. The overall study population consisted of 9,684 subjects (3,858 men, 5,826 women) with a mean age of 47.73 ± 8.08 to 48.87 ± 9.26 years respectively. They were divided into four categories based on their PAL. Biochemical parameters were determined for all participants. Also, serum anti-HSP-27 levels were measured using an in-house enzyme-linked immune sorbent assay method. Multiple regression analysis was used to explore the association between the anti-HSP antibody titers and physical activity after adjusting for confounding factors. The level of statistical significance was set at p 
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2021.102316