DOG1 expression is common in human tumors: A tissue microarray study on more than 15,000 tissue samples

DOG1 (Discovered on GIST1) is a voltage-gated calcium-activated chloride and bicarbonate channel that is highly expressed in interstitial cells of Cajal and in gastrointestinal stromal tumors (GIST) derived from Cajal cells. To systematically determine in what tumor entities and normal tissue types...

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Published in:	Pathology, research and practice research and practice, 2021-12, Vol.228, p.153663-153663, Article 153663
Main Authors:	Jansen, Kristina, Farahi, Nagina, Büscheck, Franziska, Lennartz, Maximilian, Luebke, Andreas M., Burandt, Eike, Menz, Anne, Kluth, Martina, Hube-Magg, Claudia, Hinsch, Andrea, Höflmayer, Doris, Weidemann, Sören, Fraune, Christoph, Möller, Katharina, Lebok, Patrick, Sauter, Guido, Simon, Ronald, Uhlig, Ria, Wilczak, Waldemar, Jacobsen, Frank, Minner, Sarah, Krech, Rainer, Clauditz, Till, Bernreuther, Christian, Dum, David, Krech, Till, Marx, Andreas, Steurer, Stefan
Format:	Article
Language:	eng
Subjects:	Anoctamin-1 - analysis Anoctamin-1 - biosynthesis Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism DOG1 Humans immunohistochemistry Neoplasm Proteins - analysis Neoplasm Proteins - biosynthesis Neoplasms - diagnosis Neoplasms - metabolism Tissue Array Analysis tissue micro array, human cancer
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Summary:	DOG1 (Discovered on GIST1) is a voltage-gated calcium-activated chloride and bicarbonate channel that is highly expressed in interstitial cells of Cajal and in gastrointestinal stromal tumors (GIST) derived from Cajal cells. To systematically determine in what tumor entities and normal tissue types DOG1 may be further expressed, a tissue microarray (TMA) containing 15,965 samples from 121 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. DOG1 immunostaining was found in 67 tumor types including GIST (95.7%), esophageal squamous cell carcinoma (31.9%), pancreatic ductal adenocarcinoma (33.6%), adenocarcinoma of the Papilla Vateri (20%), squamous cell carcinoma of the vulva (15.8%) and the oral cavity (15.3%), mucinous ovarian cancer (15.3%), esophageal adenocarcinoma (12.5%), endometrioid endometrial cancer (12.1%), neuroendocrine carcinoma of the colon (11.1%) and diffuse gastric adenocarcinoma (11%). Low level-DOG1 immunostaining was seen in 17 additional tumor entities. DOG1 expression was unrelated to histopathological parameters of tumor aggressiveness and/or patient prognosis in cancers of the breast (n = 1002), urinary bladder (975), ovary (469), endometrium (173), stomach (233), and thyroid gland (512). High DOG1 expression was linked to estrogen receptor expression in breast cancer (p
ISSN:	0344-0338 1618-0631