Additional Effect of Coronary High-Intensity Plaque on T1-Weighted Magnetic Resonance Imaging With Circulating Malondialdehyde-Modified Low-Density Lipoprotein on Cardiac Events

Background:Although elevated levels of oxidized low-density lipoprotein (LDL) could play a critical role in vulnerable plaque, there are no studies that have compared coronary high-intensity plaque (HIP) and circulating malondialdehyde-modified (MDA)-LDL levels for the prediction of cardiac events.M...

Full description

Saved in:
Bibliographic Details
Published in:Circulation Journal 2021/10/25, Vol.85(11), pp.2032-2039
Main Authors: Hiraya, Daigo, Sato, Akira, Hoshi, Tomoya, Sakai, Shunsuke, Watabe, Hiroaki, Ieda, Masaki
Format: Article
Language:English
Subjects:
Cardiac events
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - therapy
Coronary high-intensity plaque
Humans
Lipoproteins, LDL
Magnetic Resonance Imaging
Malondialdehyde
Malondialdehyde-modified low-density lipoprotein
Percutaneous Coronary Intervention
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background:Although elevated levels of oxidized low-density lipoprotein (LDL) could play a critical role in vulnerable plaque, there are no studies that have compared coronary high-intensity plaque (HIP) and circulating malondialdehyde-modified (MDA)-LDL levels for the prediction of cardiac events.Methods and Results:A total of 139 patients with coronary artery stenosis (>70%) were examined with non-contrast T1-weighted magnetic resonance imaging (MRI) (HIP: n=64, non-HIP: n=75). Scheduled percutaneous coronary intervention (PCI) for culprit lesions was performed within 48 h after MRI. HIP was defined as a signal intensity of coronary plaque to cardiac muscle ratio (PMR) ≥1.4. We evaluated the subsequent major adverse cardiac events (MACE) during the follow-up period (5.6±1.3 years). MDA-LDL levels were independently associated with the presence of HIP (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-21-0220