Circulating heat shock protein 27 (HSPB1) levels in prediction of pre‐eclampsia: A pilot study

Objective To determine whether circulating heat shock proteins HSP27/HSPB1 and HSP90α/HSPC1 may be useful for early prediction of the occurrence of pre‐eclampsia in asymptomatic women. Methods We have measured by ELISA the levels of HSPB1, HSPC1, and placental protein 13 (PP13) in serum samples from...

Full description

Saved in:
Bibliographic Details
Published in:International journal of gynecology and obstetrics 2022-07, Vol.158 (1), p.93-100
Main Authors: Martin, Raquel L., Sottile, Mayra L., Redondo, Analia L., Gomez, Laura C., Gauna, Gisel V., Flamini, Marina I., Grajeda, Carina, Anzalone, Alfonsa C., Rodriguez‐Echandia, Eduardo, Nadin, Silvina B., Vargas‐Roig, Laura M.
Format: Article
Language:English
Subjects:
HSP27/HSPB1
placental protein 13
prediction
pre‐eclampsia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To determine whether circulating heat shock proteins HSP27/HSPB1 and HSP90α/HSPC1 may be useful for early prediction of the occurrence of pre‐eclampsia in asymptomatic women. Methods We have measured by ELISA the levels of HSPB1, HSPC1, and placental protein 13 (PP13) in serum samples from 44 women in the first trimester (10–12 weeks) and second trimester (17–20 weeks) of pregnancy. Western blot and immunohistochemistry for HSPB1 and HSPC1 were performed. Results HSPB1 serum levels were higher in women with pre‐eclampsia than in normotensive pregnant women at the first and second trimester (P = 0.003), whereas PP13 levels decreased in women with pre‐eclampsia only in the first trimester of gestation (P = 0.021). We also observed higher HSPB1 levels in patients with early‐onset pre‐eclampsia in the first and second trimester (P = 0.014). Conclusion This pilot study points out that circulating HSPB1 levels in first and second trimester might be useful for predicting the occurrence of pre‐eclampsia in asymptomatic women. Further validation studies are needed to finally establish this protein as a candidate predictive biomarker of pre‐eclampsia. Circulating heat shock protein 27 (HSPB1) levels in first and second trimester might be useful for predicting the occurrence of pre‐eclampsia in asymptomatic women.
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.13982