Nutritional status and functional status of the pancreatic cancer patients and the impact of adjacent symptoms

Pancreatic cancer (PC) is the third most common type of gastrointestinal tract cancer in Europe and the fourth leading cause of death by cancer. Its initial stage is asymptomatic Therefore, the diagnosis tends to be late leading to locally advanced stages that presuppose late and debilitating sympto...

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Published in:	Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-11, Vol.40 (11), p.5486-5493
Main Authors:	Santos, I., Mendes, L., Mansinho, H., Santos, C.A.
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Cachexia - diagnosis Cachexia - etiology Cachexia - mortality Female Functional Status Hand Strength Humans Male Malnutrition Malnutrition - diagnosis Malnutrition - etiology Malnutrition - mortality Malnutrition GLIM criteria Mass Screening Middle Aged Nutrition Assessment Nutritional Status Pancreatic cancer Pancreatic Neoplasms - complications Pancreatic Neoplasms - mortality Pancreatic Neoplasms - physiopathology Prevalence Prognosis Risk Assessment Symptoms Weight Loss
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Summary:	Pancreatic cancer (PC) is the third most common type of gastrointestinal tract cancer in Europe and the fourth leading cause of death by cancer. Its initial stage is asymptomatic Therefore, the diagnosis tends to be late leading to locally advanced stages that presuppose late and debilitating symptoms, which consequently makes the Nutritional Status (NS) get worse. The weight loss (WL), malnutrition, and oncologic cachexia, which are quite prevalent in PC patients, reflect a poor prognosis. We aimed to track and evaluate the NS and Functional Status (FS) of PC patients (hospitalized patients – HP and Day Hospital patients – DHP) and associate NS with symptoms with nutritional impact and FS. Observational cohort study in PC patients from Garcia de Orta Hospital. NS was tracked and evaluated using Nutritional Risk Screening (NRS-2002) and Patient-Generated Subjective Global Assessment (PG-SGA). To assess FS we used the Eastern Cooperative Oncology Group (ECOG), Karnofsky Performance Scale Index (KPSI) and Handgrip Dynamometer (HGD). 41 PC patients (30-HP and 11-DHP). 29 patients in stage IV of the tumor. 24 with a WL >10% in the last 6 months. 37 manifest symptoms with nutritional impact. 30 to 34 malnourished according to the GLIM criteria and PG-SGA, respectively. 11 in ECOG level 2 and corresponding KPSI, 10 in level 3 and 8 in level 4. 28 patients had a value of HGD below the 10th percentile. NRS-2002, PG-SGA and GLIM criteria were positively correlated with the symptoms (p
ISSN:	0261-5614 1532-1983