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Induced and spontaneous IgE antibodies to Dermatophagoides farinae in dogs and cats: evidence of functional heterogeneity of IgE
Enzyme‐linked immunosorbent assays (ELISAs) were developed to measure IgE antibodies specific for Dermatophagoides farinae in dogs and cats. Although higher levels were detected in atopic dogs and cats than in normal animals without skin disease, the differences were not statistically significant. O...
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Published in: | Veterinary dermatology 1998-09, Vol.9 (3), p.179-184 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Enzyme‐linked immunosorbent assays (ELISAs) were developed to measure IgE antibodies specific for Dermatophagoides farinae in dogs and cats. Although higher levels were detected in atopic dogs and cats than in normal animals without skin disease, the differences were not statistically significant. On the other hand, levels in dogs and cats that were reared under laboratory conditions, and thus presumably not exposed to house dust mites, were either very low or undetectable. IgE antibodies were induced in 10 laboratory‐reared cats using low‐dose antigenic stimulation in aluminium hydroxide. All cats developed detectable IgE, but not all developed positive skin tests. However, serum from those cats with positive skin tests were able to give positive Prausnitz–Küstner (PK) tests. The canine data, together with previous work on basophil histamine release, suggests that the distinction between atopic and normal dogs may result from a heterogeneity of either IgE or of the high‐affinity mast cell receptor. The feline data can only be explained by the existence of a heterogeneity of IgE. |
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ISSN: | 0959-4493 1365-3164 |
DOI: | 10.1046/j.1365-3164.1998.00112.x |