Dopamine-Mediated Biomineralization of Calcium Phosphate as a Strategy to Facilely Synthesize Functionalized Hybrids

Organic–inorganic hybrid materials have been considered to be promising carriers or immobilization matrixes for biomolecules due to their high efficiency and significantly enhanced activities and stabilities of biomolecules. Here, the well-defined dopamine/calcium phosphate organic–inorganic hybrids...

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Bibliographic Details
Published in:The journal of physical chemistry letters 2021-10, Vol.12 (41), p.10235-10241
Main Authors: Sun, Nan, Jia, Yi, Wang, Chenlei, Xia, Jiarui, Dai, Luru, Li, Junbai
Format: Article
Language:English
Subjects:
Biomineralization
Calcium Phosphates - chemistry
Dopamine - chemistry
Drug Delivery Systems
Molecular Structure
Particle Size
Physical Insights into Chemistry, Catalysis, and Interfaces
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Summary:Organic–inorganic hybrid materials have been considered to be promising carriers or immobilization matrixes for biomolecules due to their high efficiency and significantly enhanced activities and stabilities of biomolecules. Here, the well-defined dopamine/calcium phosphate organic–inorganic hybrids (DACaPMFs) are fabricated via one-pot dopamine-mediated biomineralization, and their structure and properties are also characterized. Direct stochastic optical reconstruction microscopy (dSTORM) is first used to probe the distribution of organic components in these hybrids. Combined with spectroscopic data, the direct observation of dopamine in the hybrids helps to understand the formation of a physical chemistry mechanism of the biomineralization. The obtained DACaPMFs with multiple-level pores allow the loading of doxorubicin with a high loading efficiency and a pH-responsive property. Furthermore, thrombin is entrapped by the hybrids to prove the controlled release. It is expected that such organic–inorganic hybrid materials may hold great promise for application in drug delivery as well as scaffold materials in bone tissue engineering and hemostatic material.
ISSN:1948-7185
1948-7185
DOI:10.1021/acs.jpclett.1c02748