Cyst or Tumor? A systematic review and meta-analysis on the expression of p53 marker in Odontogenic Keratocysts

The odontogenic keratocyst (OKC) is a potentially aggressive odontogenic lesion and there is an ongoing debate regarding its biological behavior and classification. The present systematic review aims to assess the expression of the p53 protein in the odontogenic keratocyst in comparison to the denti...

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Bibliographic Details
Published in:Journal of cranio-maxillo-facial surgery 2021-12, Vol.49 (12), p.1101-1106
Main Authors: Slusarenko da Silva, Yuri, Stoelinga, Paul J.W., Grillo, Ricardo, da Graça Naclério-Homem, Maria
Format: Article
Language:English
Subjects:
Ameloblastoma
Biomarkers
Dentigerous Cyst
Humans
Jaw Neoplasms
Keratocysts
Odontogenic Cysts
Odontogenic Tumors
Organization
Tumor
Tumor Suppressor Protein p53 - genetics
World health
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Summary:The odontogenic keratocyst (OKC) is a potentially aggressive odontogenic lesion and there is an ongoing debate regarding its biological behavior and classification. The present systematic review aims to assess the expression of the p53 protein in the odontogenic keratocyst in comparison to the dentigerous cyst and ameloblastoma. We searched MEDLINE, Web of Science and Scopus for immunohistochemical studies reporting OKC's, dentigerous cysts and solid/multicystic ameloblastomas. The Risk Difference between the lesions expressing the p53 was the effect measure and a P value 
ISSN:1010-5182
1878-4119
DOI:10.1016/j.jcms.2021.09.015