Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

This pilot study assessed the glycaemic control and the serum levels of inflammatory mediators in type 2 diabetes (T2DM) patients with apical periodontitis (AP). Thirty individuals were divided into four groups: Healthy (H); with AP (AP); with T2DM (T2DM); and with T2DM and AP (T2DM‐AP). Demographic...

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Bibliographic Details
Published in:Australian endodontic journal 2022-04, Vol.48 (1), p.105-115
Main Authors: Stys, Liliana Preto Agostini, Böttcher, Daiana Elisabeth, Scarparo, Roberta Kochenborger, Gonçalves Waltrick, Silvana Beltrami, Figueiredo, José Antonio Poli, Gomes, Maximiliano Schünke, Campos, Maria Martha
Format: Article
Language:English
Subjects:
Aged
Antihypertensives
apical periodontitis
Biomarkers
blood glucose
Body mass index
CCL3 protein
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Endodontics
Female
Glucose
Glycated Hemoglobin A - analysis
Gum disease
Hemoglobin
Humans
Inflammation
Interleukin 6
Male
Metformin
Middle Aged
oral health
Patients
Periapical Periodontitis
Periodontitis
Pilot Projects
Serum levels
systemic inflammation
type 2 diabetes mellitus
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Summary:This pilot study assessed the glycaemic control and the serum levels of inflammatory mediators in type 2 diabetes (T2DM) patients with apical periodontitis (AP). Thirty individuals were divided into four groups: Healthy (H); with AP (AP); with T2DM (T2DM); and with T2DM and AP (T2DM‐AP). Demographic and pharmacological data were registered. The body mass index (BMI) and the levels of glycated haemoglobin (HbA1c) and IL‐1β, IL‐6, IL‐10, CCL3 and CCL4 were evaluated. AP areas were determined radiographically. Mean age was 64 ± 12 years, with 63% females. Most T2DM patients were under treatment with metformin and antihypertensives. BMI and H1bAc were significantly higher in T2DM patients in relation to H and AP groups. The AP areas were larger in the T2DM‐AP group, compared with the AP group. These preliminary findings suggest no influence of AP on glycaemic control or inflammatory levels amongst T2DM patients, although T2DM increased the AP severity.
ISSN:1329-1947
1747-4477
DOI:10.1111/aej.12569