Clinical outcome in patients with primary epithelial ovarian cancer and germline BRCA1/2-mutation – real life data

We evaluated the clinical impact of germline (g)BRCA1/2-mutation on initial disease presentation, surgical implications, surgical morbidity and survival in patients with advanced epithelial ovarian cancer (EOC) undergoing debulking surgery (DS). Data of all consecutive EOC patients with stage III/IV...

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Bibliographic Details
Published in:Gynecologic oncology 2021-12, Vol.163 (3), p.569-577
Main Authors: Ataseven, Beyhan, Tripon, Denise, Schwameis, Richard, Harter, Philipp, Rhiem, Kerstin, Schneider, Stephanie, Heikaus, Sebastian, Baert, Thaïs, Francesco, Alesina Pier, Heitz, Florian, Traut, Alexander, Groeben, Harald-Thomas, Schmutzler, Rita, du Bois, Andreas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
BRCA1 Protein - genetics
BRCA2 Protein - genetics
Carcinoma, Ovarian Epithelial - genetics
Carcinoma, Ovarian Epithelial - surgery
Epithelial ovarian cancer
Female
gBRCA1/2-mutation
Germ-Line Mutation
Humans
Middle Aged
Ovarian Neoplasms - genetics
Ovarian Neoplasms - surgery
Postoperative complication
Postoperative Complications - etiology
Retrospective Studies
Surgical outcome
Survival
Treatment Outcome
Young Adult
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Summary:We evaluated the clinical impact of germline (g)BRCA1/2-mutation on initial disease presentation, surgical implications, surgical morbidity and survival in patients with advanced epithelial ovarian cancer (EOC) undergoing debulking surgery (DS). Data of all consecutive EOC patients with stage III/IV, high-grade serous disease and known gBRCA1/2 status (gBRCA; non-gBRCA), who underwent DS at our department between 01/2011 and 06/2019 were analyzed. Associations between gBRCA-status and severe postoperative complications and survival were analyzed. gBRCA-status was determined in 50.1% (612/1221) of all patients. gBRCA was present in 21.9% (134/612). Significant differences were observed in terms of median age (p = 0.001) and histology (high-grade serous histology gBRCA: 98.5%, non-gBRCA 76.2%; p 
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2021.09.004