Tannic acid protects aged brain against cerebral hypoperfusion via modulation of Nrf2 and inflammatory pathways

[Display omitted] •Tannic acid improves brain metabolism and blood flow in oligemia.•Tannic acid decreases neurodegeneration level after hypoperfusion.•Tannic acid exhibits protective effects against locomotion and working memory deficit. Current study purposed to investigate the neuroprotective eff...

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Bibliographic Details
Published in:Neuroscience letters 2021-11, Vol.765, p.136263-136263, Article 136263
Main Authors: Sehati, Fardin, Ahmadi, Iraj, Farivar, Nika, Ranjbaran, Mina, Sadat-Shirazi, Mitra-sadat, Nabavizadeh, Fatemeh, Mahla Shavakandi, Seyyedeh, Ashabi, Ghorbangol
Format: Article
Language:English
Subjects:
Aged
Aging - immunology
Animals
Apoptosis
Brain - diagnostic imaging
Brain - drug effects
Brain - immunology
Cerebral hypoperfusion
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - immunology
Disease Models, Animal
Humans
Ischemia
Locomotion - drug effects
Locomotion - immunology
Male
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Neuroinflammatory Diseases - diagnosis
Neuroinflammatory Diseases - immunology
Neuroinflammatory Diseases - prevention & control
Neuroprotective Agents - administration & dosage
NF-E2-Related Factor 2 - metabolism
Nrf2
Oxidative Stress - drug effects
Oxidative Stress - immunology
Positron-Emission Tomography
Rat
Rats
Tannic acid
Tannins - administration & dosage
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Summary:[Display omitted] •Tannic acid improves brain metabolism and blood flow in oligemia.•Tannic acid decreases neurodegeneration level after hypoperfusion.•Tannic acid exhibits protective effects against locomotion and working memory deficit. Current study purposed to investigate the neuroprotective effects of Tannic Acid (TA) on mild chronic cerebral hypoperfusion model in rats. Male Wistar rats were subjected to permanent Unilateral Common Carotid Artery Occlusion (UCCAO), followed by TA treatment (0.05% w/v) in drinking water for one month. Nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H: quinone oxidoreductase 1 (NQO-1), heme oxygenase-1 (HO-1), factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3, blood triglyceride, blood glucose, and liver enzymes’ activity were detected after the experimental period. Also, behavioral tests, hematoxylin and eosin (H&E) staining, and PET scan were performed after treatment. Post-treatment of TA improved locomotion and memory function (P 
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2021.136263