Amniotic membrane extract eye drops: a new approach to severe ocular surface pathologies

A protocol for processing amniotic membrane as an extract to be re-hydrated and administered topically as eye drops (amniotic membrane extract eye drops, AMEED) has been developed. Safety and efficacy of AMEED was assessed in patients with severe ocular surface pathologies. prospective clinical foll...

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Bibliographic Details
Published in:Cell and tissue banking 2022-09, Vol.23 (3), p.473-481
Main Authors: Pérez, Maria Luisa, Barreales, Saúl, Sabater-Cruz, Noelia, Martinez-Conesa, Eva Maria, Vilarrodona, Anna, Casaroli-Marano, Ricardo P.
Format: Article
Language:English
Subjects:
Amniotic membrane
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cornea
Eye diseases
Full Length Paper
Life Sciences
Patients
Pruritus
Sensation
Statistical analysis
Stem cells
Transplant Surgery
Ulcers
Visual perception
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Summary:A protocol for processing amniotic membrane as an extract to be re-hydrated and administered topically as eye drops (amniotic membrane extract eye drops, AMEED) has been developed. Safety and efficacy of AMEED was assessed in patients with severe ocular surface pathologies. prospective clinical follow-up of ocular surface symptoms before and after regular application of the AMEED for at least 4 weeks on patients with severe ocular surface disorders as chronic dry eye disease, limbal stem cell deficiency, neurotrophic ulcer and permanent and disabling symptomatology that were refractory to conventional treatment. Efficacy and tolerability were assessed based on patient-reported symptoms, objective measurements, and reports of adverse events. Thirty-six eyes from 25 patients were included. Although the visual quality function score, by means of a VQF25 questionnaire, was not statistically different after the treatment (p = 0.4657), there was a clear trend, statistically significant, towards the improvement in ocular symptoms like foreign body sensation, itching and stinging (p 
ISSN:1389-9333
1573-6814
DOI:10.1007/s10561-021-09962-4